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The denatured state dictates the topology of two proteins with almost identic...
The protein folding problem is often studied by comparing the mechanisms of proteins sharing the same structure but different sequence. The recent design of the two... -
Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domain...
Protein-protein interactions mediated by modular protein domains are critical for cell scaffolding, differentiation, signaling, and ultimately, evolution. Given the... -
Enhanced F508del-CFTR channel activity ameliorates bone pathology in murine c...
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