@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00995617v1> a dcat:Dataset ;
    dct:description """
              Reprogramming cellular gene transcription sustains HTLV-1 viral persistence that ultimately leads to the development of adult T-cell leukemia/lymphoma (ATLL). We hypothesized that besides these quantitative transcriptional effects. HTLV-1 quantitatively modifies the pattern of cellular gene expression. Exon expression analysis shows that patients’ untransformed and malignant HTLV-1+ CD4+ T-cells exhibit multiple alternate exon usage (AEU) events. These affect either transcriptionally modified or unmodified genes, culminate in ATLL, and unveil new functional pathways involved in cancer and cell cycle. A total of 486 exon modifications occurred in untransformed infected CD4+ cells were detected in ATLL arguing for a role of AEUs in HTLV-1 leukemogenesis. Unsupervised hierarchical clustering of array data permitted to isolate exon expression patters of 3977 exons that discriminate uninfected, infected, and transformed CD4+ T-cells. Exposing cells to splicing inhibitors revealed that Sudemycin E reduces cell viability of HTLV-1 transformed cells without affecting primary control CD4+ cells and HTLV-1 negative cell lines, suggesting that the huge excess of AEU might provides news targets for treating ATLL. Taken together, these data reveal that HTLV-1 significantly modifies the structure of cellular transcripts and unmask new putative leukemogenic pathways and possible therapeutic targets
            """ ;
    dct:identifier "NNT: 2014LYO10059" ;
    dct:issued "2026-05-05T10:22:45.885226"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-05T10:22:45.885230"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Deregulation of alternative splicing during HTLV-1 infection : role of Tax" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00995617v1/resource/c19d55ea-4411-493f-8c02-f8c42b7c8141> ;
    dcat:keyword "alternative-splicing",
        "arn-polymerase",
        "epissage-alternatif",
        "htlv-1",
        "infoeu-reposemanticsdoctoralthesis",
        "nf-kb",
        "rna-polymerase-ii",
        "sdvsalife-sciences-q-bioagricultural-sciences",
        "tax",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00995617> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00995617v1/resource/c19d55ea-4411-493f-8c02-f8c42b7c8141> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-05T10:22:45.889868"^^xsd:dateTime ;
    dct:modified "2026-05-05T10:22:45.873665"^^xsd:dateTime ;
    dct:title "Deregulation of alternative splicing during HTLV-1 infection : role of Tax" ;
    dcat:accessURL <https://theses.hal.science/tel-00995617> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00995617> a foaf:Document .