Methodology to improve the accuracy of the non-invasive diagnosis of liver fibrosis in chronic hepatitis C
type: Distribution
access URL: https://theses.hal.science/tel-00982618
format: HTML
issued: 2026-05-05T13:27:01.482114
modified: 2026-05-05T13:27:01.463098

test_moissonnage_selune
type: Agent

Methodology to improve the accuracy of the non-invasive diagnosis of liver fibrosis in chronic hepatitis C
type: Dataset
contact point: Organization
  fn: CCSD
keyword: fibroscan
keyword: infoeu-reposemanticsdoctoralthesis
keyword: biopsie
keyword: fibrose
keyword: hepatite-chronique-c
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
keyword: tests-non-invasifs
keyword: methodologie
keyword: theses
keyword: test-sanguins-de-fibrose
landing page: https://theses.hal.science/tel-00982618
description: Prognosis and management of patients with chronic hepatitis C depends on the degree of liver fibrosis which is classically assessed by histological examination of a liver biopsy. However, liver biopsy is an invasive procedure and histological examination is impaired by sampling bias and fair reproductibility. Recently, new tests allow for a non-invasive evaluation of liver fibrosis : fibrosis blood tests and transient elastography (Fibroscan). Since December 2008, the French Health Authority has recommanded these tests as first-line exams for the assessment of fibrosis/cirrhosis in patients with chronic hepatitis C. However, these recommendations do not specify the practical use of these tests. In addition, the accuracy of non-invasive fibrosis tests has mainly been globally evaluated and the implement a methodology to improve the accuracy of the non-invasive diagnosis of liver fibrosis in hepatitis C. We developed several methodological concepts : fibrosis tests adapted to the diagnostic target, synchronous combinations of tests, association of intervals of reliable diagnosis. These new concepts were finally used to develop a new non-invasive classification of liver fibrosis, easy to use and very significantly more accurate than those actually used in clinical practice.
issued: 2026-05-05T13:27:01.474246
language: fr
modified: 2026-05-05T13:27:01.474250