synthesis of polycyclic molecules by intramolecular palladium-catalyzed C(sp³)-H arylation
type: Dataset
description: The direct functionalization of C-H bonds constitutes a faster and more « atom-economical »synthetic approach. This concept is gradually modifying organic chemistry, because itprovides chemists of both academic and industrial worlds with new disconnection strategies,giving access to molecules of original structures and properties in a more efficient andecological manner.In this context, we first investigated the extension of the intramolecular palladium-catalyzedC(sp3)-H arylation, by using aryl chlorides as coupling partners. This methodology wasapplied to the synthesis of fused valuable five-membered carbocycles and heterocycles.A further part of this work focused on the synthesis of polycyclic molecules by double C-Harylations. Interestingly, a single batch of catalyst was able to perform both operations in onepot, which indicates that this concept can be used for the rapid construction of molecularcomplexity.Then, we focused our efforts on the enantioselective synthesis of indanes and heterocyclicanalogues by intramolecular C(sp3)-H arylation. The employment of a chiral binepine ligandplays a key role in this palladium-catalyzed process to achieve moderate to highstereoinduction.Finally, our work was devoted to the construction of fused thiophenes by intramolecular PdIIcatalyzeddeshydrogenative C(sp3)–H arylation.
landing page: https://theses.hal.science/tel-00975446
identifier: NNT: 2012LYO10207
keyword: activation-c-h
keyword: activation-c-h-asymetrique
keyword: arylation-c-h
keyword: asymmetric-c-h-activation
keyword: benzocyclobutenes
keyword: c-h-activation
keyword: c-h-arylation
keyword: c-h-functionalization
keyword: catalyse-organometallique
keyword: chimothechemical-sciencesother
keyword: chloroarenes
keyword: fonctionnalisation-c-h
keyword: infoeu-reposemanticsdoctoralthesis
keyword: organometallic-catalysis
keyword: palladium
keyword: theses
issued: 2026-05-05T15:59:32.023001
modified: 2026-05-05T15:59:32.023007
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

synthesis of polycyclic molecules by intramolecular palladium-catalyzed C(sp³)-H arylation
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00975446
issued: 2026-05-05T15:59:32.028270
modified: 2026-05-05T15:59:32.003987