@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00968161v1> a dcat:Dataset ;
    dct:description """
              Quiescent neural stem cells (NSCs) are considered the reservoir for adult neurogenesis, generating new neurons throughout life. However, neurogenesis decreases during aging, causing a progressive decline that is currently untreatable. To study the regulatory mechanisms of NSCs proliferation, we set up a new technique allowing the isolation of quiescent NSCs and their progeny. We show that GABAAR directly regulates NSCs quiescence in vivo as the depletion of GABA-producing neuroblasts or GABAAR pathway pharmacological blockade provoked NSCs cell cycle entry in the SVZ. During aging, the stock of NSCs is not perturbed, but we show that an over-production of TGFβ1 by brain endothelial cells directly lengthens activated NSCs G1 phase, strongly decreasing the production of new neurons. These findings highlight GABAAR and TGF-β/Smad-3 as two major pathways controlling NSCs proliferation. In line with a future therapeutic application, we also prove that their blocking stimulates endogenous neurogenesis in vivo.
            """ ;
    dct:identifier "NNT: 2013PA112204" ;
    dct:issued "2026-05-05T19:31:11.537883"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-05T19:31:11.537886"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Characterization of the factors regulating the proliferation of adult neural stem cells" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00968161v1/resource/f1c155d7-dce0-464c-a747-78aa8fe7dade> ;
    dcat:keyword "adult-neurogenesis",
        "aging",
        "cellule-souche-neurale",
        "cytometrie-en-flux",
        "flow-cytometry",
        "gaba",
        "infoeu-reposemanticsdoctoralthesis",
        "irradiation",
        "neural-stem-cell",
        "neurogenese-adulte",
        "sdvsalife-sciences-q-bioagricultural-sciences",
        "tgf-beta",
        "theses",
        "vieillissement" ;
    dcat:landingPage <https://theses.hal.science/tel-00968161> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00968161v1/resource/f1c155d7-dce0-464c-a747-78aa8fe7dade> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-05T19:31:11.554705"^^xsd:dateTime ;
    dct:modified "2026-05-05T19:31:11.521984"^^xsd:dateTime ;
    dct:title "Characterization of the factors regulating the proliferation of adult neural stem cells" ;
    dcat:accessURL <https://theses.hal.science/tel-00968161> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00968161> a foaf:Document .