@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              Androgens signaling through the androgen receptor (AR) is critical for normal prostate development and function, as well as prostate cancer initiation and progression. The discovery of new effectors of androgens-AR pathway will allow a better understanding of these mechanisms.MiR-135a has been identified as a target gene in androgen-AR signaling pathway. After androgen stimulation, AR directly activates the transcription of miR-135a2 gene by binding to an androgen response element in the promoter region.Ectopic expression of miR-135a was found to induce morphological modification leading to an inhibition of migration and invasion in prostate cancer cells, by down-regulating ROCK1 and ROCK 2 expression, two newly identified miR-135a target genes.Moreover, miR-135a targets and downregulates the expression of the transcription factor FOXN3, able to modulate AR transcriptional activity and androgen-mediated cell proliferation.Thus, functional study of miR-135a suggests that it could be implicated in prostate cancer progression, by regulating metastases formation and androgen signaling.MiR-135a expression level in surgical cancerous speciments normalized to pair-matched normal counterpart tissues was inversely correlated with aggressivity parameters of the disease, suggesting that it could be used as a candidate prognostic marker in human prostate cancer.These results define miR-135a as a novel effector in androgens-AR signaling, which may contribute to prostate cancer progression.
            """ ;
    dct:identifier "NNT: 2013ENSL0834" ;
    dct:issued "2026-05-05T21:07:32.344371"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-05T21:07:32.344377"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Androgen regulation of microRNA miR-135a and its implication in prostate cancer progression" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00965286v1/resource/6f54c623-98bd-44db-a676-016dff81aedc> ;
    dcat:keyword "androgen-receptor",
        "cancer-de-la--prostate",
        "foxn3",
        "infoeu-reposemanticsdoctoralthesis",
        "microarn",
        "microrna",
        "mir-135a",
        "prostate-cancer",
        "recepteur-aux-androgenes",
        "rock1",
        "rock2",
        "sdvbbmbmlife-sciences-q-biobiochemistry-molecular-biologymolecular-biology",
        "sdvbclife-sciences-q-biocellular-biology",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00965286> .

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    dct:format "HTML" ;
    dct:issued "2026-05-05T21:07:32.359666"^^xsd:dateTime ;
    dct:modified "2026-05-05T21:07:32.321491"^^xsd:dateTime ;
    dct:title "Androgen regulation of microRNA miR-135a and its implication in prostate cancer progression" ;
    dcat:accessURL <https://theses.hal.science/tel-00965286> .

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    foaf:name "test_moissonnage_selune" .

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