Epidemiological study of infections causing Pseudomonas aeruginosa strains and their bacteriophages for therapeutic approach.
type: Dataset
description: The use of viruses of bacteria commonly called bacteriophages could constitute an efficient complement to antibiotics. During my PhD, I have characterized phages infecting the opportunistic pathogen Pseudomonas. aeruginosa, responsible for lung infections in cystic fribrosis patients. Firstly, I investigated the efficiency of Pyophage (a cocktail of phages therapeutic Georgian) on clinical P. aeruginosa strains and recovered six lytic phages from four different genus. The Pyophage appears to be unactive on approximately 15% of clinical strains. Secondly, and using multi-phages resistant strains as enrichment bacteria, 32 phages were isolated from waste water of France and Côte d’Ivoire. All phages are tailed and distributed within ten different genus including six exclusively lytic. I identified bacterial strains which remain insensitive to all phages. I also demonstrated that the CRISPRs-cas system plays no role in the resistance of strains to lytic phages.
identifier: NNT: 2013PA112072
issued: 2026-05-05T22:53:32.357147
language: fr
modified: 2026-05-05T22:53:32.357151
contact point: Organization
  fn: CCSD
keyword: bacteriophages
keyword: cystic-fibrosis
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mlva
keyword: mucoviscidose
keyword: phage-therapy
keyword: phagotherapie
keyword: pseudomonas-aeruginosa
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: theses
landing page: https://theses.hal.science/tel-00962607

Epidemiological study of infections causing Pseudomonas aeruginosa strains and their bacteriophages for therapeutic approach.
type: Distribution
format: HTML
issued: 2026-05-05T22:53:32.364563
modified: 2026-05-05T22:53:32.336545
access URL: https://theses.hal.science/tel-00962607

test_moissonnage_selune
type: Agent