@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              The purpose of this work is to expand foldamer diversity by developing a novel class of abiotic β-sheet-like architectures. Our strategy uses inter-strand π-π aromatic stacking between sequences of aromatic oligoamides and oligoamines to mimic the natural stabilization of β-strands, which occurs through a network of regularly spaced hydrogen bonds. These oligamide and oligoamine sequences are connected by a rigid U-shaped moiety that creates a turn and initiates strand formation.These molecules have been designed to adopt compact folded structures that can be studied in solution by NMR spectroscopy and in the solid state by X-ray crystallography. In the first part of this dissertation, we report our stepwise approach in the development of β-sheet-like aromatic amide-based foldamers: from the optimization of the design elements and the use of macrocycles, to the synthesis of multi-turn structures. In the second part, the concept will be extented to the synthesis of more elaborate curving strand β-sheet-like foldamers, opening up new perspectives for more complex architectures.
            """ ;
    dct:identifier "NNT: 2013BOR14844" ;
    dct:issued "2026-05-06T02:51:37.719558"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-06T02:51:37.719562"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Design, synthesis and structural studies of ß-sheet-like aromatic amide-based foldamers" ;
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            vcard:fn "CCSD" ] ;
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    dcat:keyword "-sheet-like-structures",
        "analyse-conformationnelle",
        "aromatic-oligoamide-foldamers",
        "aromatic-stacking",
        "auto-organisation",
        "chimie-supramoleculaire",
        "chimothechemical-sciencesother",
        "conformation-analysis",
        "cristallographie-par-diffraction-des-rayons-x",
        "empilement-aromatique",
        "foldameres-doligoamides-aromatiques",
        "hydrogen-bonds",
        "infoeu-reposemanticsdoctoralthesis",
        "liaisons-hydrogenes",
        "self-organization",
        "structures-en-feuillet",
        "supramolecular-chemistry",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00956734> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00956734v1/resource/d7c1bc0e-c5b5-48ec-aee6-61955f5dfb6b> a dcat:Distribution ;
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    dct:issued "2026-05-06T02:51:37.754755"^^xsd:dateTime ;
    dct:modified "2026-05-06T02:51:37.690453"^^xsd:dateTime ;
    dct:title "Design, synthesis and structural studies of ß-sheet-like aromatic amide-based foldamers" ;
    dcat:accessURL <https://theses.hal.science/tel-00956734> .

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