Biofunctional self-assemblies from polymer-b-peptide conjugates
type: Dataset
description: This thesis work deals with preparation and study of cell-penetrating self-assemblies from amphiphilicpolymer-b-peptide Tat-b-poly(trimethylene carbonate) conjugates. Tat-b-PTMC chimeras withtunable hydrophilic fractions were synthesized, thoroughly characterized and self-assembled inaqueous buffer into size-tunable, highly monodisperse core-shell nanoparticles, presenting a full Tatcorona. Their physico-chemical profiles were assessed by complementary imaging (AFM, TEM) andscattering techniques (multiangle DLS, SANS) and correlated with their molecular architectures.Their transduction ability in vitro on HeLa cells and interaction mode with phospholipid membraneswere studied with a view to correlate their physico-chemical profiles with their biological properties.This interdisciplinary approach partially shed light on the interactions at play in the cellular uptakeprocess. With the ultimate goal of improving pharmacological characteristics, we finally endeavoredto develop an ON/OFF PEGylation strategy to harness the cell penetrating power of thosebiomacromolecular self-assembled systems.
landing page: https://theses.hal.science/tel-00951878
identifier: NNT: 2013BOR14896
keyword: amphiphilic-conjugates
keyword: auto-assemblage
keyword: biofonctional-nanoparticles
keyword: cell-penetrating-micelles
keyword: cellular-uptake
keyword: chimeres-amphiphiles
keyword: chimothechemical-sciencesother
keyword: infoeu-reposemanticsdoctoralthesis
keyword: internalisation-cellulaire
keyword: nanoparticules-biofonctionnelles
keyword: peptide-tat
keyword: polymer-b-peptide
keyword: polymere-b-peptide
keyword: ptmc
keyword: self-assembly
keyword: tat-peptide
keyword: theses
issued: 2026-05-06T06:00:45.162377
modified: 2026-05-06T06:00:45.162383
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Biofunctional self-assemblies from polymer-b-peptide conjugates
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00951878
issued: 2026-05-06T06:00:45.202386
modified: 2026-05-06T06:00:45.140719