Biofunctional self-assemblies from polymer-b-peptide conjugates
type: Distribution
access URL: https://theses.hal.science/tel-00951878
format: HTML
issued: 2026-05-06T06:00:45.202386
modified: 2026-05-06T06:00:45.140719

test_moissonnage_selune
type: Agent

Biofunctional self-assemblies from polymer-b-peptide conjugates
type: Dataset
contact point: Organization
  fn: CCSD
keyword: amphiphilic-conjugates
keyword: ptmc
keyword: self-assembly
keyword: internalisation-cellulaire
keyword: peptide-tat
keyword: cellular-uptake
keyword: chimeres-amphiphiles
keyword: nanoparticules-biofonctionnelles
keyword: auto-assemblage
keyword: tat-peptide
keyword: theses
keyword: cell-penetrating-micelles
keyword: biofonctional-nanoparticles
keyword: chimothechemical-sciencesother
keyword: infoeu-reposemanticsdoctoralthesis
keyword: polymer-b-peptide
keyword: polymere-b-peptide
landing page: https://theses.hal.science/tel-00951878
description: This thesis work deals with preparation and study of cell-penetrating self-assemblies from amphiphilicpolymer-b-peptide Tat-b-poly(trimethylene carbonate) conjugates. Tat-b-PTMC chimeras withtunable hydrophilic fractions were synthesized, thoroughly characterized and self-assembled inaqueous buffer into size-tunable, highly monodisperse core-shell nanoparticles, presenting a full Tatcorona. Their physico-chemical profiles were assessed by complementary imaging (AFM, TEM) andscattering techniques (multiangle DLS, SANS) and correlated with their molecular architectures.Their transduction ability in vitro on HeLa cells and interaction mode with phospholipid membraneswere studied with a view to correlate their physico-chemical profiles with their biological properties.This interdisciplinary approach partially shed light on the interactions at play in the cellular uptakeprocess. With the ultimate goal of improving pharmacological characteristics, we finally endeavoredto develop an ON/OFF PEGylation strategy to harness the cell penetrating power of thosebiomacromolecular self-assembled systems.
identifier: NNT: 2013BOR14896
issued: 2026-05-06T06:00:45.162377
language: fr
modified: 2026-05-06T06:00:45.162383