@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              The general main topic of this work was the use and the development of cleavable linkers in biological systems. This study led to the design of a cleavable enrichment probe in non-denaturing conditions for chemical proteomic applications. In a topoisomerase analysis, this probe allowed the extraction and analysis of a functional DNA gyrase A2B2 complex. For fluorescence imaging, a new concept of chemically deactivatable quencher was introduced. This quencher was used to revealinactivated FRET-based probe in cell experiments. Finally, a methodology based on biolability measurements of acid-sensitive molecules was developed for the evaluation of chemical bond lability in native biological environments. This work was focused on biolability measurements of acidsensitive molecules.
            """ ;
    dct:identifier "NNT: 2012STRAF062" ;
    dct:issued "2026-05-06T14:53:41.468083"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-06T14:53:41.468091"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Study of cleavable bonds in biological medium and their applications in chemical proteomics and fluorescence imaging" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00945942v1/resource/ac7da178-8485-4a88-8acc-ce505e390d48> ;
    dcat:keyword "bio-acidite",
        "bio-labilite",
        "bioacidity",
        "biolability",
        "chemical-proteomic",
        "chimothechemical-sciencesother",
        "cleavable-linker",
        "deactivatable-quencher",
        "fluorescence-imaging",
        "fret",
        "imagerie-de-fluorescence",
        "infoeu-reposemanticsdoctoralthesis",
        "lien-clivable",
        "non-denaturant",
        "non-denaturing",
        "proteomique-chimique",
        "quencheur-desactivable",
        "sonde-pro-fluorescente",
        "theses",
        "turn-on-probe" ;
    dcat:landingPage <https://theses.hal.science/tel-00945942> .

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    dct:format "HTML" ;
    dct:issued "2026-05-06T14:53:41.542741"^^xsd:dateTime ;
    dct:modified "2026-05-06T14:53:41.405014"^^xsd:dateTime ;
    dct:title "Study of cleavable bonds in biological medium and their applications in chemical proteomics and fluorescence imaging" ;
    dcat:accessURL <https://theses.hal.science/tel-00945942> .

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    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00945942> a foaf:Document .