The control of selective autophagy and tumor reprogramming through the scaffold protein SQSTM1
type: Dataset
contact point: Organization
  fn: CCSD
keyword: infoeu-reposemanticsdoctoralthesis
keyword: tumorigenesis
keyword: autophagy
keyword: autophagie
keyword: cadmium
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: tumor-metabolism
keyword: tumorigenese
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: metabolisme-tumoral
keyword: rhoa
keyword: sqstm1
keyword: theses
landing page: https://theses.hal.science/tel-00945776
description: Despite recent advances, cancer remains the leading cause of death in France with~150,000 annual deaths (INCA, 2012). Notably, lung cancer is one of the most aggressive, with 29 100 deaths in 2011. The five-year survival is only 10 % of patients with lung cancer non-small cell (NSCLC, 80% of lung cancers), so it’s a medical/scientific challenge, and public health problem. Due to genetic instability, it’s commonly accepted that a subpopulation of tumor acquires new aggressive properties for its dissemination, its proliferation and greater resistance to chemotherapy. A better understanding of these tumor properties is a major issue to prevent this malignant progression. We focused our research on macro-autophagy, a lysosomal catabolic process essential for cellular homeostasis, and alos on one of its substrates SQSTM1 (Sequestosome or p62). When I started my PhD, a close relationship between autophagy, SQSTM1 and tumor progression had been highlighted. Several members of the autophagic machinery are frequently mutated/deleted in cancers. Paradoxically, autophagy can also allow the survival of tumor cells under hypoxia, nutritional deficiency or chemotherapy. How could we understand these conflicting functions, considering that the only autophagy substrates known are long half-lives proteins, damaged organelles and scaffold SQSTM1? Thus, SQSTM1 is essential for RasV12 driven oncogenesis (A Duran et al, Cancer Cell 2008).
identifier: NNT: 2013NICE4145
issued: 2026-05-06T15:27:19.739516
language: fr
modified: 2026-05-06T15:27:19.739521

test_moissonnage_selune
type: Agent

The control of selective autophagy and tumor reprogramming through the scaffold protein SQSTM1
type: Distribution
access URL: https://theses.hal.science/tel-00945776
format: HTML
issued: 2026-05-06T15:27:19.753441
modified: 2026-05-06T15:27:19.709317