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    dct:description """
              The type 1 diabetes ( T1D ) is an autoimmune disease characterized by the destruction of β cells in the pancreas by autoreactive T lymphocytes. During my thesis, we are interested in the role of cells of innate immunity in T1D using a mouse model of the disease: NOD mice. In contrast to cells of the adaptive system (T and B lymphocytes ) cells of innate immunity is the first line of defense of the body during infection . This population consists of neutrophils , among other , plasmacytoid dendritic cells ( pDC ) , macrophages , T lymphocytes but not conventional B as iNKT cells and B -1a.Previously, our laboratory has highlighted the role of iNKT cells in the development of T1D . During the first part of my thesis , we demonstrated that iNKT17 cells, a subpopulation of iNKT cells, have a deleterious role in T1D in NOD mice . These cells infiltrate the pancreas and there produce IL -17 , a proinflammatory cytokine. Through transfer experiments , we demonstrated that lymphocytes iNKT17 exacerbate disease through the production of IL-17 . In the second part of my thesis , we investigated the mechanisms that induce the activation of autoreactive T lymphocytes. We observed in NOD mice , the physiological death of β cells leads to activation of innate immunity cells : neutrophils, lymphocytes B- 1a and pDCs . The cooperation between these cells leads to activation of pDC that produce IFNa . This cytokine activates autoreactive T cells which will destroy the β cells of the pancreas. Our results show that innate immunity is an important player in the pathogenesis of diabetes mellitus.
            """ ;
    dct:identifier "NNT: 2013PA05T074" ;
    dct:issued "2026-05-07T00:28:13.424011"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-07T00:28:13.424016"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Innate immunity in diabetes mellitus" ;
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    dcat:keyword "diabete",
        "diabete-de-type-1",
        "diabetes",
        "immunite-innee",
        "infoeu-reposemanticsdoctoralthesis",
        "innate-immunity",
        "lymphocytes-t",
        "mait",
        "nkt",
        "nod-mice",
        "obesite",
        "obesity",
        "sdvmheplife-sciences-q-biohuman-health-and-pathology",
        "souris-nod",
        "t-lymphocytes",
        "theses",
        "type-1-diabetes" ;
    dcat:landingPage <https://theses.hal.science/tel-00944309> .

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    dct:modified "2026-05-07T00:28:13.400791"^^xsd:dateTime ;
    dct:title "Innate immunity in diabetes mellitus" ;
    dcat:accessURL <https://theses.hal.science/tel-00944309> .

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