Stereoselective synthesis of heteroaryl alcohols and alanines
type: Dataset
description: This PhD thesis presents the stereoselecticve synthesis of several novel amino acids and secondary alcohols using biocatalysis. The work is divided in two main parts.The first part is dedicated to the stereoselective synthesis of novel heteroaryl alanines using two different biocatalysts with the same enantiopreference, the aminoacylase I and the baker's yeast (Saccharomyces cerevisiae). Using these two biocatalysts the L-alanines were obtained with a high enantiometric excess and yields.The second part is dedicated to the syntehsis of the txo enantiomers of the novel (hetero)aryl secondary alcohols using lipases as the biocatalysts. This part is divided in two sub-chapters, one for the stereoselective synthesis of (S)- and (R)-1-aryl-3-chloro propanols and the other for the streoselective synthesis of different (thiazole-2-yl)-methanols C-substituted and their acylated derivatives. These compounds were obtained by the stereoselective enzymatic acylation of the racemic alcohols and the enzymatic hydrolisis ot their acylatic derivatives.
identifier: NNT: 2011ISAM0025
issued: 2026-05-07T04:15:48.496796
language: fr
modified: 2026-05-07T04:15:48.496801
contact point: Organization
  fn: CCSD
keyword: acide-amine
keyword: alcools-secondaires
keyword: amino-acids
keyword: bakers-yeast
keyword: biotransformation
keyword: chimothechemical-sciencesother
keyword: infoeu-reposemanticsdoctoralthesis
keyword: levure-de-boulanger
keyword: lipase
keyword: methode-de-mosher
keyword: resolution-cinetique-enzymatique
keyword: secondary-alcohols
keyword: synthese-stereoselective
keyword: theses
landing page: https://theses.hal.science/tel-00940020

Stereoselective synthesis of heteroaryl alcohols and alanines
type: Distribution
format: HTML
issued: 2026-05-07T04:15:48.498207
modified: 2026-05-07T04:15:48.481954
access URL: https://theses.hal.science/tel-00940020

test_moissonnage_selune
type: Agent