Adaptation interactive d'un traitement de radiothérapie par imagerie volumique : Développement et validation d'outils pour sa mise en œuvre en routine clinique
type: Dataset
description: Changing anatomy during radiotherapy can lead to significant dosimetric consequences for organs at risk (OARs) and/or target volumes. Adaptive radiotherapy can compensate for these variations however its deployment for clinical work is hampered by the increased workload for the medical staff and there is still no commercialized software available for clinical use. We developed a simple in vivo dosimetric alert tool allowing rapid identification of patients who might benefit from an adaptive radiotherapy. Dosimetric evaluation of delivered treatment has been conducted onto 3D on board imaging (CBCT) whose dose calculation accuracy has been evaluated. The tool does not require a new volume of interest delineation. Tool alert is based on objectives and quantifiable criteria defined by the exceeding volumes of interest dose thresholds. Tool precision and detectability have been validated and applied in a retrospective study on 10 head and neck patients. The tool allows detecting patients where an adaptive treatment could have been considered. In its clinical implementation, adaptive radiotherapy process requires deformable matching algorithms to follow patient local's deformations occurring during treatment. Nevertheless, their use has not been validated. We conducted an evaluation of the Block Matching deformable algorithm, suitable for multimodality imaging (CT/CBCT), in comparison to rigid algorithm. A study has been conducted for 10 head and neck patients based on volume of interest contours comparison for 76 CBCT. Similarity parameters used consisted on Dice Similarity Index, Robust Hausdorff Distance (in mm) and the absolute volume difference (in cc)
issued: 2026-05-07T05:31:25.534244
language: fr
modified: 2026-05-07T05:31:25.534248
contact point: Organization
  fn: CCSD
keyword: 3d-imaging
keyword: alerte-dosimetrique
keyword: art
keyword: deformable-image-matching
keyword: dgrt
keyword: dosimetric-alert
keyword: igrt
keyword: imagerie-3d
keyword: infoeu-reposemanticsdoctoralthesis
keyword: orl
keyword: recalage-deformable-dimages
keyword: sdviblife-sciences-q-biobioengineering
keyword: theses
landing page: https://theses.hal.science/tel-00937604

Adaptation interactive d'un traitement de radiothérapie par imagerie volumique : Développement et validation d'outils pour sa mise en œuvre en routine clinique
type: Distribution
format: HTML
issued: 2026-05-07T05:31:25.541284
modified: 2026-05-07T05:31:25.519659
access URL: https://theses.hal.science/tel-00937604

test_moissonnage_selune
type: Agent