Recombinant human erythropoietin and renin-angiotensin aldosterone system induced hypertension and vascular disease : Effect of exercise and T regulatory cells
type: Dataset
description: Hypertension (HTN) is one of the most frequent disease and is of greatest concern in Western countries.HTN is often associated with overweight, kidney, heart and endocrine system disease. Vasculardisorders, associated with HTN induced by erythropoietin (r-HuEPO) treatment in chronic kidneydisease or in case of disruption of the renin-angiotensin-aldosterone system (RAAS), associated increasein arterial stiffness, endothelial dysfunction, unbalanced endothelin-1/nitric oxide ratio (ET-1/NO) andinflammation. Vascular inflammation contributes to the pathophysiology of hypertension by increasingoxidative stress and activation of immune cells. Several studies have suggested that the immune systemis involved in the development of cardiovascular disease. However, the role of regulatory T cells (Treg)in HTN and other forms of cardiovascular diseases remains largely unknown. In addition, most of thestudies have shown that hypertension induced by r-HuEPO is related to endothelial dysfunction and theratio (ET-1/NO). The exact mechanisms remain to be identified. Several studies have shown thatphysical exercise prevents HTN in patients or animal models. The aim of the first part of this work is tostudy the impact of shear stress and exercise on HTN and vascular disorders induced by r-HuEPO, in thepresence of an endothelial imbalance (ET-1/NO). This was carried out in three settings: in vitro (culturecells), ex vivo (mesenteric arteries) and in vivo (transgenic mice overexpressing ET-1 in endothelialcells). Our results show that the association L-NAME/r-HuEPO is responsible for a significant decreasein intravascular diameter, in response to elevated intravascular flow resulting in a flow-dependentvasoconstriction and increased corresponding shear stress (more than 25 dyn/cm2). Bosentan (a nonselectiveantagonist of ET-1 receptors) inhibits flow-dependent vasoconstriction induced by thecombination L-NAME/rHu-EPO without correcting vasodilation. Treatment of ET-1 transgenic micewith…
identifier: NNT: 2011AVIG0705
issued: 2026-05-07T15:33:42.580202
language: fr
modified: 2026-05-07T15:33:42.580207
contact point: Organization
  fn: CCSD
keyword: cellules-t-regulatrices
keyword: endothelin-1
keyword: endotheline-1
keyword: exercice
keyword: exercise
keyword: hypertension
keyword: infoeu-reposemanticsdoctoralthesis
keyword: r-huepo
keyword: regulatory-t-cells
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: shear-stress
keyword: theses
keyword: treg
landing page: https://theses.hal.science/tel-00924322

Recombinant human erythropoietin and renin-angiotensin aldosterone system induced hypertension and vascular disease : Effect of exercise and T regulatory cells
type: Distribution
format: HTML
issued: 2026-05-07T15:33:42.590616
modified: 2026-05-07T15:33:42.561596
access URL: https://theses.hal.science/tel-00924322

test_moissonnage_selune
type: Agent