@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923721v1> a dcat:Dataset ;
    dct:description """
              Pneumonia is the leading cause of death in children worldwide. It can be caused by a number of known pathogens, but 15-35% of childhood pneumonia are still not associated with an etiologic agent. A pathogen discovery assay allowed us to identify new species of Torque Teno Mini Virus (TTMV, Anelloviridae), named TTMV-LY, in three undiagnosed pleural effusions from children hospitalized with parapneumonic empyema. TTMV are ubiquitous orphan viruses, and their involvement in pathogenesis remains unknown. The respiratory tract was previously described to be a site of anellovirus detection. We investigated the role of these new species in the pathogenesis of severe pneumonia.Full-length TTMV-LY genomes were isolated and in vitro replicated. The response of alveolar epithelial cells, and antigen presenting cells (APC), both involved in the inflammation process, was studied after infection with neo-synthesized virions.This study showed for the first time that: i) TTMV-LY can deeply colonize lungs, ii) alveolar epithelial cells are permissive to the TTMV-LY and allow an efficient replication, iii) viral infection modulates cellular and innate immune responses of alveolar epithelial cells, by inducing gene expression deregulations and inflammatory mediators production, iv) TTMV-LY are able to interact with APC and thereby regulate differentially their inflammatory process.All these results allowed to highlight a potential involvement of TTMV-LY in the pathogenesis of severe pneumonia and brought out the complexity of the biological mechanisms taking place during infection by viruses of this family.
            """ ;
    dct:identifier "NNT: 2013ENSL0809" ;
    dct:issued "2026-05-07T15:54:15.144886"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-07T15:54:15.144893"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Isolation and characterization of new species of Torque Teno Mini Virus (TTMV) : potential implication in the pathogenesis of pneumonia" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923721v1/resource/6cbf2988-96f1-4fa1-8cf4-64dadae0da0f> ;
    dcat:keyword "deregulation-de-lexpression-genique",
        "epanchement-pleural",
        "gene-expression-deregulation",
        "infoeu-reposemanticsdoctoralthesis",
        "innate-immune-response",
        "mediateurs-inflammatoires-solubles",
        "parapneumonic-effusion",
        "phylogenie",
        "phylogeny",
        "pneumonia",
        "pneumonie",
        "replication-virale",
        "reponse-immunitaire-innee",
        "sdvbclife-sciences-q-biocellular-biology",
        "sdvmhepmilife-sciences-q-biohuman-health-and-pathologyinfectious-diseases",
        "soluble-inflammatory-mediators",
        "theses",
        "ttmv",
        "viral-replication" ;
    dcat:landingPage <https://theses.hal.science/tel-00923721> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923721v1/resource/6cbf2988-96f1-4fa1-8cf4-64dadae0da0f> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-07T15:54:15.153602"^^xsd:dateTime ;
    dct:modified "2026-05-07T15:54:15.123075"^^xsd:dateTime ;
    dct:title "Isolation and characterization of new species of Torque Teno Mini Virus (TTMV) : potential implication in the pathogenesis of pneumonia" ;
    dcat:accessURL <https://theses.hal.science/tel-00923721> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00923721> a foaf:Document .