test_moissonnage_selune
type: Agent

Malaria associated with pregnancy : Immunological consequences in pregnant women and newborn
type: Dataset
contact point: Organization
  fn: CCSD
keyword: immunology
keyword: paludisme
keyword: grossesse
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
keyword: infoeu-reposemanticsdoctoralthesis
landing page: https://theses.hal.science/tel-00923172
description: The objective of this thesis was to investigate the immunological consequences of pregnancy associated malaria (PAM) in pregnant women and their newborns. The study populations comprise sub-groups drawn from a longitudinal study known as “Strategies TO Prevent Pregnancy Associated Malaria” (STOPPAM) that was conducted in parallel in the two study sites i.e. Benin and Tanzania. The STOPPAM objectives were to elucidate the mechanisms and course of PAM and quantify the effects of PAM on mothers and their childhood’s health. First, we characterized cell mediated-immunity from P. falciparum-infected or non-infected pregnant women. Two studies were carried out in two sub-groups of pregnant women at early pregnancy and at delivery. In the first study, we observed a decrease frequency of T cells independently of malaria infection in the twenty-four pregnant women matched at early pregnancy and at delivery. In the second study, we characterized: i) the frequency and the level of activation of cell mediated-immunity and ii) quantify the plasma level of cytokine and chemokine in sub-groups at early pregnancy and at delivery. We observed that malaria infected pregnant women enhanced qualitative and quantitative changes in cells frequencies early during pregnancy and at delivery. The main finding of this study was the B cells activation at any time of infection and the decreased frequency of Treg at early pregnancy. PAM enhanced also higher levels of IL-10, IP-10 and MIG in our sub-groups. These bio-markers were identified as risk factors of placental infection at delivery. These observations suggest the management of malaria control in pregnant women in early pregnancy. The second part of this thesis was focused on the impact of PAM on neonatal innate immune responses. In a first study, we characterized antigen-presenting cells (APC) in cord blood as a function of placental malaria infection or inflammation of the placenta. Our results showed that the presence of malaria pigmen…
identifier: NNT: 2013PA05P611
issued: 2026-05-07T16:17:44.077494
language: fr
modified: 2026-05-07T16:17:44.077501

Malaria associated with pregnancy : Immunological consequences in pregnant women and newborn
type: Distribution
access URL: https://theses.hal.science/tel-00923172
format: HTML
issued: 2026-05-07T16:17:44.081240
modified: 2026-05-07T16:17:44.069992