@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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              In tumors, invasive cancer cells induce matrix metalloproteinase 11 (MMP-11) expression in adjacent adipocytes (cancer-associated adipocytes), leading to their « dedifferentiation » into fibroblast-like cells. Indeed, MMP-11 is a negative regulator of adipogenesis. During my PhD, I have investigated MMP-11 function during postnatal mammary gland development. The ductal tree and alveolar structures, and milk production are reduced in MMP-11-deficient mice. Moreover, MMP-11 plays a role in collagen homeostasis. Transplantation experiments show that MMP-11 exerts an essential local paracrine function for ductal morphogenesis. Using primary mammary organoids, I show that adipocyte-related MMP-11 is a pro-branching factor in vitro. Thus, MMP-11 is a master paracrine factor during mammary gland development. Finally, to further investigate the adipocyte-related MMP-11 function, I have developed conditional transgenic mice targeting MMP-11 expression specifically into adipocytes.
            """ ;
    dct:identifier "NNT: 2012STRAJ032" ;
    dct:issued "2026-05-07T16:19:57.555643"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-07T16:19:57.555647"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Study of matrix métalloprotéases 11 function in adipocyte-epithelial cell interaction/crosstalk in the mammary gland" ;
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    dcat:keyword "adipocyte",
        "cellule-epitheliale",
        "collagen",
        "collagene",
        "developpement",
        "epithelial-cell",
        "glande-mammaire",
        "infoeu-reposemanticsdoctoralthesis",
        "mammary-gland-development",
        "mmp-11",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology",
        "sdvmheplife-sciences-q-biohuman-health-and-pathology",
        "stroma",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00923160> .

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    dct:title "Study of matrix métalloprotéases 11 function in adipocyte-epithelial cell interaction/crosstalk in the mammary gland" ;
    dcat:accessURL <https://theses.hal.science/tel-00923160> .

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