@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923149v1> a dcat:Dataset ;
    dct:description """
              In the goal of modeling anxio/depressive states, our group has created two mouse models for using different approaches: knockout mice for both 5-HT1A and 5-HT1B receptors (5-HT1A/1B-/-) and stressed mice induced by long-term exposure of exogenous corticosterone (CORT model). These models display a hyper-anxious and an anxio-depressive phenotype, respectively. Using advantage of microarrays, we aimed at characterizing the molecular phenotype in different cortico-limbic brain regions of these mice associated with the behavioral impairments observed in these mice and we investigate the effects of antidepressants on the transcriptome. Our studies showed that anxious/depressive states in mice induced specific transcriptome changes in different brain regions of cortico-limbic circuit. Chronic antidepressant treatment did not only reverse these changes in gene expression, but also induced region-specific genomic transcripts.
            """ ;
    dct:identifier "NNT: 2012PA114838" ;
    dct:issued "2026-05-07T16:18:17.666088"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-07T16:18:17.666093"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Gene expression profiles analyses in mouse models of anxiety / depression" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923149v1/resource/a7c96a48-c521-4858-8a8c-983814a7696c> ;
    dcat:keyword "5-ht1a-and-5-ht1b-receptors",
        "amygdala",
        "amygdale",
        "antidepressants",
        "antidepresseurs",
        "behavioral-tests",
        "cingulate-cortex",
        "cortex-cingulaire",
        "hippocampe",
        "hippocampus",
        "infoeu-reposemanticsdoctoralthesis",
        "microarray",
        "neurogenese",
        "neurogenesis",
        "puces-a-adn",
        "recepteurs-5-ht1a-et-5-ht1b",
        "sdvmheplife-sciences-q-biohuman-health-and-pathology",
        "serotonin",
        "serotonine",
        "tests-comportementaux",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00923149> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00923149v1/resource/a7c96a48-c521-4858-8a8c-983814a7696c> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-07T16:18:17.669628"^^xsd:dateTime ;
    dct:modified "2026-05-07T16:18:17.645861"^^xsd:dateTime ;
    dct:title "Gene expression profiles analyses in mouse models of anxiety / depression" ;
    dcat:accessURL <https://theses.hal.science/tel-00923149> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00923149> a foaf:Document .