test_moissonnage_selune
type: Agent

Gene expression profiles analyses in mouse models of anxiety / depression
type: Distribution
access URL: https://theses.hal.science/tel-00923149
format: HTML
issued: 2026-05-07T16:18:17.669628
modified: 2026-05-07T16:18:17.645861

Gene expression profiles analyses in mouse models of anxiety / depression
type: Dataset
contact point: Organization
  fn: CCSD
keyword: amygdale
keyword: antidepresseurs
keyword: amygdala
keyword: antidepressants
keyword: theses
keyword: puces-a-adn
keyword: neurogenese
keyword: infoeu-reposemanticsdoctoralthesis
keyword: recepteurs-5-ht1a-et-5-ht1b
keyword: hippocampe
keyword: behavioral-tests
keyword: 5-ht1a-and-5-ht1b-receptors
keyword: cingulate-cortex
keyword: hippocampus
keyword: cortex-cingulaire
keyword: serotonin
keyword: serotonine
keyword: microarray
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: neurogenesis
keyword: tests-comportementaux
landing page: https://theses.hal.science/tel-00923149
description: In the goal of modeling anxio/depressive states, our group has created two mouse models for using different approaches: knockout mice for both 5-HT1A and 5-HT1B receptors (5-HT1A/1B-/-) and stressed mice induced by long-term exposure of exogenous corticosterone (CORT model). These models display a hyper-anxious and an anxio-depressive phenotype, respectively. Using advantage of microarrays, we aimed at characterizing the molecular phenotype in different cortico-limbic brain regions of these mice associated with the behavioral impairments observed in these mice and we investigate the effects of antidepressants on the transcriptome. Our studies showed that anxious/depressive states in mice induced specific transcriptome changes in different brain regions of cortico-limbic circuit. Chronic antidepressant treatment did not only reverse these changes in gene expression, but also induced region-specific genomic transcripts.
identifier: NNT: 2012PA114838
issued: 2026-05-07T16:18:17.666088
language: fr
modified: 2026-05-07T16:18:17.666093