test_moissonnage_selune
type: Agent

Phytochemistry of Zanthoxylum chiloperone var. angustifolium (Rutaceae). Chemistry and pharmacochemistry of canthin-6-one
type: Dataset
contact point: Organization
  fn: CCSD
keyword: tuberculosis
keyword: theses
keyword: alkaloids
keyword: chagas
keyword: infoeu-reposemanticsdoctoralthesis
keyword: natural-products
keyword: prenylation
keyword: cancer
keyword: nematicide
keyword: substances-naturelles
keyword: bischler-napierlaski
keyword: biomomethic-chemistry
keyword: canthin-6-one
keyword: bischler-napieraslki
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: rutaceae
keyword: indoles
keyword: eta-carbolines
landing page: https://theses.hal.science/tel-00923141
description: The alkaloids canthin-6-one, 5-methoxy-canthin-6-one and canthin-6-one Noxide,as well as the alkylamide sanshool and three known coumarines were identified and quantified from stem bark, leaves (in this case an annual analysis was conducted), fruits and roots of Zanthoxylum chiloperone var. angustifolium (Rutaceae) collected in South America. Some canthin-6-one derivates were prepared by hemisynthesis by exploring the N-3 reactivity of the pyridine nitrogen. Other new derivates were prepared from different tryptamines and some functionalized anhydrides by an efficient new synthetic route (3 or 4 steps) in good overall yields. The biosynthetic pathway of the canthin-6-one was also chemically explored.Furthermore, this work has prompted us to explore the reactivity of some prenylated derivates of canthin-6-one and serotonin. The antitubercular activity, the antiproliferative activity on cancer stem cells and several antiparasitic activities (Chagas disease, malaria, nematicidal activity) were studied and various mechanisms of action proposed. Finally, an original study of the electrochemical behaviour of canthinones has been investigated and a pharmaceutical formulation was achieved.
identifier: NNT: 2011PA114844
issued: 2026-05-07T16:22:17.692751
language: fr
modified: 2026-05-07T16:22:17.692756

Phytochemistry of Zanthoxylum chiloperone var. angustifolium (Rutaceae). Chemistry and pharmacochemistry of canthin-6-one
type: Distribution
access URL: https://theses.hal.science/tel-00923141
format: HTML
issued: 2026-05-07T16:22:17.704470
modified: 2026-05-07T16:22:17.675841