@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00922996v1> a dcat:Dataset ;
    dct:description """
              The work reported in this manuscript concerns the development of a new approach to a family of natural butyrolactames, with a high therapeutic potential, based on a [2+2] cycloaddition reaction followed by a ring expansion. In the main part, a procedure for the preparation of highly functionalized cyclobutanones by [2+2] cycloaddition between chiral enols ethers and functionalized ketenes has been developed. With this method, a variety of cyclobutanones were obtained in a highly chemo-, regio- and stéréosélective manner. The ring expansion of the previously prepared cyclobutanones to obtain the butyrolactame skeleton of (–)-Salinosporamide A was next investigated. The last part of this manuscript consists in a study of the [2+2] cycloaddition reaction between ketene and enol ether activated by a Lewis acid in catalytic amount. This first study seems to point out that an activation of [2+2] cycloaddition reaction is possible when a sterically hindered enol ether is used.
            """ ;
    dct:identifier "NNT: 2012GRENV058" ;
    dct:issued "2026-05-07T16:25:10.906974"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-07T16:25:10.906978"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "From chiral cylobutanones to (-)-Salinosporamide A" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00922996v1/resource/498a9b12-f77a-4a49-8ad7-8c1a0f1588c6> ;
    dcat:keyword "cetene-dissymetrique",
        "cetene-symetrique",
        "cycle-expansion",
        "cycloaddition",
        "expansion-de-cycle",
        "infoeu-reposemanticsdoctoralthesis",
        "lactame",
        "natural-products",
        "produits-naturels",
        "sdvsalife-sciences-q-bioagricultural-sciences",
        "symmetric-ketene",
        "theses",
        "unsymmetric-ketene" ;
    dcat:landingPage <https://theses.hal.science/tel-00922996> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00922996v1/resource/498a9b12-f77a-4a49-8ad7-8c1a0f1588c6> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-07T16:25:10.908331"^^xsd:dateTime ;
    dct:modified "2026-05-07T16:25:10.891614"^^xsd:dateTime ;
    dct:title "From chiral cylobutanones to (-)-Salinosporamide A" ;
    dcat:accessURL <https://theses.hal.science/tel-00922996> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00922996> a foaf:Document .