@prefix dcat: . @prefix dct: . @prefix foaf: . @prefix vcard: . @prefix xsd: . a dcat:Dataset ; dct:description """ These scientific project deals with synthesis and functionalization of nitrogen heterocycles catalyzed by transition metals. The first part of this project was devoted to the development of a simple and efficient reaction for the N-cyclopropylation of various nitrogen compounds. From cyclopropylboronic acid under copper oxidative coupling conditions, a wide variety of nitrogen compounds have been N-cyclopropylated. This method allows a new access to N-cyclopropylated substrates.The second part of this work deals with benzimidazoles synthesis. These nitrogen heterocycles have been obtained from amidines through a sequence involving a N-arylation reaction followed by cyclization via a C-H bond functionalization.The third part of this manuscript focuses on pyrroles synthesis. Pyrroles are known for their abundance in biologically active molecules. We have developed a new sequential one-pot procedure for poly-functionalized N-H pyrroles synthesis. Through a enaminone formation catalyzed by indium (III), followed by a palladium catalyzed heteroannulation, various N-H pyrroles have been synthesizedThe final part of this scientific project describes our approach to total synthesis of an alkaloid: the (-)-norsuavéoline. The specificity of our approach was based on the formation of pyridine ring in the beginning of the synthesis and a late formation of indole ring. To date, we have developed and optimized the pyridine synthesis from L-(-)-glutamic acid. Studies are ongoing in the laboratory to obtain the indole part and complete the synthesis of this natural product. """ ; dct:identifier "NNT: 2011PA112310" ; dct:issued "2026-05-08T00:20:57.339490"^^xsd:dateTime ; dct:language "fr" ; dct:modified "2026-05-08T00:20:57.339494"^^xsd:dateTime ; dct:publisher ; dct:title "Synthesis and functionalization of nitrogen heterocycle catalyzed by metal transition. Toward the total synthesis of (-)-norsuaveoline." ; dcat:contactPoint [ a vcard:Organization ; vcard:fn "CCSD" ] ; dcat:distribution ; dcat:keyword "--norsuaveoline", "alcaloide", "alkaloid", "benzimidazoles", "catalyse", "catalysis", "chimothechemical-sciencesother", "copper", "couplage-en-conditions-oxydantes", "cuivre", "heteroannelation", "heteroannulation", "heterocycles-azotes", "infoeu-reposemanticsdoctoralthesis", "n-cyclopropylation", "nitrogen-heterocycles", "oxidative-cross-coupling", "palladium", "pyrroles", "theses" ; dcat:landingPage . a dcat:Distribution ; dct:format "HTML" ; dct:issued "2026-05-08T00:20:57.344537"^^xsd:dateTime ; dct:modified "2026-05-08T00:20:57.321517"^^xsd:dateTime ; dct:title "Synthesis and functionalization of nitrogen heterocycle catalyzed by metal transition. Toward the total synthesis of (-)-norsuaveoline." ; dcat:accessURL . a foaf:Agent ; foaf:name "test_moissonnage_selune" . a foaf:Document .