Influence of the stroma and the mesenchymal stem cells on the epithelial ovarian cancer spreading and resistance to treatment
type: Dataset
description: Patients with epithelial ovarian cancer (EOC) are diagnosed with advanced stage in 75% of cases and most of them will relapse despite a good primary response to chemotherapy, thus explaining the bad prognosis of EOC. While tumor microenvironment seems to play an important role for the development and survival of cancer cells, there is only few data regarding the mesenchymal stem cells (MSC) in EOC. In this work we therefore aimed at identifying the molecular determinant between MSC and ovarian cancer cells. In the first part of this work, we demonstrated that ovarian cancer cells acquired pro-metastatic profile upon contact with MSC. We then showed that MSC could enhance ovarian cancer cells infiltration through IL6 secretion in an amniochorionic membrane based 3D model. Finally we showed that MSC could protect ovarian cancer cells from hyperthermia through CXCL12 secretion. Taken together, our data are concordant to reveal the pro-tumoral properties of MSC. Cytokine inhibitors interrupting the cross-talk between OCC and MSC should now be tested as new therapies for EOC.
landing page: https://theses.hal.science/tel-00907889
identifier: NNT: 2012PA11T072
keyword: cancer-de-lovaire
keyword: cellule-souche-mesenchymateuse
keyword: chemoresistance
keyword: chimioresistance
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mesenchymal-stem-cells
keyword: metastase
keyword: metastasis
keyword: ovarian-cancer
keyword: sdvbclife-sciences-q-biocellular-biology
keyword: stroma
keyword: theses
issued: 2026-05-08T03:36:21.108833
modified: 2026-05-08T03:36:21.108838
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Influence of the stroma and the mesenchymal stem cells on the epithelial ovarian cancer spreading and resistance to treatment
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00907889
issued: 2026-05-08T03:36:21.125143
modified: 2026-05-08T03:36:21.095274