Influence of the stroma and the mesenchymal stem cells on the epithelial ovarian cancer spreading and resistance to treatment
type: Dataset
contact point: Organization
  fn: CCSD
keyword: mesenchymal-stem-cells
keyword: metastasis
keyword: theses
keyword: chimioresistance
keyword: infoeu-reposemanticsdoctoralthesis
keyword: sdvbclife-sciences-q-biocellular-biology
keyword: cancer-de-lovaire
keyword: ovarian-cancer
keyword: metastase
keyword: cellule-souche-mesenchymateuse
keyword: chemoresistance
keyword: stroma
landing page: https://theses.hal.science/tel-00907889
description: Patients with epithelial ovarian cancer (EOC) are diagnosed with advanced stage in 75% of cases and most of them will relapse despite a good primary response to chemotherapy, thus explaining the bad prognosis of EOC. While tumor microenvironment seems to play an important role for the development and survival of cancer cells, there is only few data regarding the mesenchymal stem cells (MSC) in EOC. In this work we therefore aimed at identifying the molecular determinant between MSC and ovarian cancer cells. In the first part of this work, we demonstrated that ovarian cancer cells acquired pro-metastatic profile upon contact with MSC. We then showed that MSC could enhance ovarian cancer cells infiltration through IL6 secretion in an amniochorionic membrane based 3D model. Finally we showed that MSC could protect ovarian cancer cells from hyperthermia through CXCL12 secretion. Taken together, our data are concordant to reveal the pro-tumoral properties of MSC. Cytokine inhibitors interrupting the cross-talk between OCC and MSC should now be tested as new therapies for EOC.
identifier: NNT: 2012PA11T072
issued: 2026-05-08T03:36:21.108833
language: fr
modified: 2026-05-08T03:36:21.108838

test_moissonnage_selune
type: Agent

Influence of the stroma and the mesenchymal stem cells on the epithelial ovarian cancer spreading and resistance to treatment
type: Distribution
access URL: https://theses.hal.science/tel-00907889
format: HTML
issued: 2026-05-08T03:36:21.125143
modified: 2026-05-08T03:36:21.095274