CELL THERAPY FOR STROKE
type: Dataset
description: Stroke is the leading cause of disability for adults. Excepted hospitalization in specialized Stroke Unit, the only treatment for ischemic stroke is thrombolysis which has to be done only during the first hours after the stroke onset. Enhance post-stroke cerebral plasticity is a major therapeutic aim. For this purpose, cell therapy, based on stem cell injection (or graft) and neural repair, leads to functional benefit in experimental models of cerebral ischemia. However, several issues remain about mechanisms of action, delivery routes, and better cell doses to use. Otherwise, only few data were obtained in humans from the first clinical trials. Our research, in the Grenoble Institut of Neurosciences (GIN U836, France), aims to assess the benefit of mesenchymal stem/stromal cell (MSC) therapy after experimental stroke, and to understand the different mechanisms of action. In parallel, we have started a phase II clinical trial of intravenous MSC after stroke (ISIS-HERMES).
issued: 2026-05-08T04:54:49.436279
language: fr
modified: 2026-05-08T04:54:49.436284
contact point: Organization
  fn: CCSD
keyword: accident-vasculaire-cerebral
keyword: avc
keyword: biotherapie
keyword: biotherapy
keyword: cell-therapy
keyword: cellules-souches-mesenchymateuses
keyword: focal-cerebral-ischemia
keyword: graft
keyword: greffe
keyword: habilitation-a-diriger-des-recherches
keyword: infoeu-reposemanticsother
keyword: irm
keyword: ischemie-cerebrale-focale
keyword: mesenchymal-stem-cells
keyword: mri
keyword: neural-repair
keyword: pathophysiology
keyword: physiopathologie
keyword: plasticite
keyword: plasticity
keyword: rat
keyword: recovery
keyword: recuperation
keyword: scconeurcognitive-scienceneuroscience
keyword: stroke
keyword: therapie-cellulaire
keyword: transplantation
landing page: https://theses.hal.science/tel-00905943

CELL THERAPY FOR STROKE
type: Distribution
format: HTML
issued: 2026-05-08T04:54:49.439962
modified: 2026-05-08T04:54:49.406704
access URL: https://theses.hal.science/tel-00905943

test_moissonnage_selune
type: Agent