Xenohormones and oral homeostasis : impact on taste preferences and salivary glands
type: Dataset
description: Oral homeostasis strongly influences taste perceptions. It depends on a healthy oral epithelium and salivary gland secretions, which are both regulated by sex hormones. The aim of this thesis was to identify the effect of an oral exposure to Bisphenol A, a food packaging and dental sealer component, and of a soy-diet containing phytoestrogens on oral homeostasisTwo experiments were conducted in adult rats: a dose-response study of BPA (5μg 12.5 mg / kj / day), and a study about the impact of a soy-diet on the BPA disrupting effects. By using gustation choice tests, and histological and qPCR-TR molecular approach, we identify for the first time an action of BPA on dry mouth. We found that BPA reduced water consumption (p <0.01), increased salt intake (p <0.05) and decreased sugar intake (p <0.05), and also modulated salivary secretions. These effects were partially reversed by stopping oral exposure. In contrast, the soy-diet increased water intake (p <10-6) and decreased in salt preference (p <0.05) by comparing to the semi-synthetic diet did, and may correct the effects of BPA.These studies show that BPA and phytoestrogens exert agonist or antagonist estrogenic effects depending on the biological target, and that a soy-based diet can erase most of the observed BPA effects
identifier: NNT: 2012DIJOS073
issued: 2026-05-08T04:57:33.196496
language: fr
modified: 2026-05-08T04:57:33.196501
contact point: Organization
  fn: CCSD
keyword: amylase
keyword: comportement-alimentaire
keyword: egf
keyword: endocrine-disruptors
keyword: food-behavior
keyword: glandes-salivaires
keyword: gustine
keyword: homeostasie-buccale
keyword: homeostasis-mouth
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mucin
keyword: mucine
keyword: perturbateurs-endocriniens
keyword: preferences-gustatives
keyword: salivary-glands
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: soif
keyword: taste-preferences
keyword: theses
keyword: thirst
landing page: https://theses.hal.science/tel-00905906

Xenohormones and oral homeostasis : impact on taste preferences and salivary glands
type: Distribution
format: HTML
issued: 2026-05-08T04:57:33.205895
modified: 2026-05-08T04:57:33.177595
access URL: https://theses.hal.science/tel-00905906

test_moissonnage_selune
type: Agent