Study of the TOR (Target Of Rapamycin) complex and signaling pathway in Arabidopsis
type: Dataset
description: The TOR (Target Of Rapamycin) kinase has first been identified in yeast and mammals as being part of two different protein complexes that are implicated in the stimulation of cell growth in response to endogenous and exogenous stimuli. Since the discovery of this kinase in Arabidopsis, some studies have been led to characterize its role in plants and the influence of its expression level on the metabolism and development regulation.In this study, I worked on the influence of the TOR inactivation on the composition of the ribosome on its protein composition and on the phosphorylation status of these proteins and also on the organisation of the meristem at a molecular and cellular level.Regarding to the results I have obtained, I showed that TOR may regulate the abundance and/or the phosphorylation status of some proteins involved in the ribosome composition. Hence, TOR inactivation leads to a decrease of the phosphorylation level of RPS6 proteins and could regulate the abundance of acid proteins constitutive of the ribosomal stalk, a structure important for the translation regulation. The results obtained also suggest that TOR activity may be necessary to keep the meristem functional by the regulation of the main important pathways controlling division and differentiation in that structure.
identifier: NNT: 2012PA112291
issued: 2026-05-09T02:59:54.006897
language: fr
modified: 2026-05-09T02:59:54.006902
contact point: Organization
  fn: CCSD
keyword: clavata3
keyword: infoeu-reposemanticsdoctoralthesis
keyword: lc-msms
keyword: meristem
keyword: meristeme
keyword: phosphoproteome
keyword: proteome
keyword: ribosome
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: theses
keyword: tor-target-of-rapamycin
keyword: wuschel
landing page: https://theses.hal.science/tel-00880882

Study of the TOR (Target Of Rapamycin) complex and signaling pathway in Arabidopsis
type: Distribution
format: HTML
issued: 2026-05-09T02:59:54.011522
modified: 2026-05-09T02:59:53.993183
access URL: https://theses.hal.science/tel-00880882

test_moissonnage_selune
type: Agent