Efficient syntheses of diversely functionalized pyrazole and pyridone derivatives and their use in siteselective cross-coupling reactions
type: Distribution
access URL: https://theses.hal.science/tel-00878928
format: HTML
issued: 2026-05-09T04:33:44.720493
modified: 2026-05-09T04:33:44.696035

test_moissonnage_selune
type: Agent

Efficient syntheses of diversely functionalized pyrazole and pyridone derivatives and their use in siteselective cross-coupling reactions
type: Dataset
contact point: Organization
  fn: CCSD
keyword: regioselectivite
keyword: suzuki-coupling
keyword: cycloaddition-13-dipolaire
keyword: fungicide
keyword: theses
keyword: infoeu-reposemanticsdoctoralthesis
keyword: pyrazole
keyword: chimothechemical-sciencesother
keyword: couplage-de-suzuki
keyword: regioselectivity
keyword: 13-dipolar-cycloaddition
keyword: fongicide
keyword: furopyridone
keyword: sydnone
landing page: https://theses.hal.science/tel-00878928
description: This thesis is subdivided into two principal parts. The first part is focussed on the synthesis of pyrazole derivatives of agrochemical relevance. Indeed, the pyrazole nucleus is found in numerous compounds possessing interesting biological properties, and notably antifungal activities. Various convergent approaches to diversely substituted pyrazoles have therefore been developed by means of site-selective palladium-catalyzed cross-coupling reactions conducted sequentially on pyrazole scaffolds. In the second part, we have been involved in the synthesis of furopyridones as simplified analogues of natural compounds possessing antifungal activities such as Cladobotryal. Toward this end, various alkynylpyridones have been synthesizes and involved in diverse cyclization processes to access a series of furo[3,2-c]pyridin-4-ones, furo[3,2-c]pyridin-6-ones, and furo[2,3-b]pyridin-4-ones
identifier: NNT: 2010LYO10274
issued: 2026-05-09T04:33:44.713146
language: fr
modified: 2026-05-09T04:33:44.713151