Characterisation, epidemiology and pathogeny of a methicillin-resistant Staphylococcus aureus clone containing the toxic shock syndrome toxin-1 gene (TSST-1)
type: Dataset
description: The plasticity of the Staphylococcus aureus genome confers to this specie the ability to gain accessory genes encoding virulence factors as well as antibiotic resistance determinants such as Staphylococcal cassette chromosome mec SCCmec that encodes methicillin-resistance. Methicillin resistance first emerged in hospital-acquired strains originally of successful nosocomial pandemic clones, and is also risen in virulent community-acquired strains containing the Panton-Valentine leucocidin. In 2002, we observed the worrying emergence of a new methicillin-resistant S. aureus (MRSA) clone that contains the tst gene encoding toxic shock syndrome toxin (TSST-1) responsible for both hospital and community-acquired infections. Our study was focused on: (i) new tools for MRSA description, mainly on a SCCmec typing tool, (ii) the characterisation of this new clone by molecular and phenotypic methods, (iii) the epidemiology of this clone, (iv) the pathogenic potential of this clone and the investigation of the genetic features that enhance transmission and virulence, particularly the role of TSST-1. The tst+ MRSA clone is an epidemic clone of genetic background ST5 by multilocus sequence typing that occurs mainly in young people and is responsible for a wide diversity of clinical syndromes including toxin-mediated and suppurative diseases. This clone harbours a peculiar cassette “truncated SCCmec type I” which could play an important role in virulence and transmission but are still under investigation. TSST-1 does not play a determining role (either directly or indirectly) in the pleiotropic pathogenesis of this clone
identifier: NNT: 2009LYO10313
issued: 2026-05-09T05:14:26.176179
language: fr
modified: 2026-05-09T05:14:26.176184
contact point: Organization
  fn: CCSD
keyword: cassette-de-resistance-a-la-meticilline
keyword: infoeu-reposemanticsdoctoralthesis
keyword: methicillin-resistance
keyword: resistance-a-la-meticilline
keyword: sdvsalife-sciences-q-bioagricultural-sciences
keyword: staphylococcal-cassette-chromosome-mec
keyword: staphylococcus-aureus
keyword: theses
keyword: toxic-shock-syndrome-toxin-1
keyword: toxine-du-choc-toxique-staphylococcique
landing page: https://theses.hal.science/tel-00878162

Characterisation, epidemiology and pathogeny of a methicillin-resistant Staphylococcus aureus clone containing the toxic shock syndrome toxin-1 gene (TSST-1)
type: Distribution
format: HTML
issued: 2026-05-09T05:14:26.182808
modified: 2026-05-09T05:14:26.164260
access URL: https://theses.hal.science/tel-00878162

test_moissonnage_selune
type: Agent