Reversion of MultiDrugResistance (MDR) phenotype by new steroids derivatives, in vitro (resistant human tumor cell line) and in vivo (xenografts models)
type: Dataset
description: The chemoresistance of cancer is characterized by a pleitropic resistance to multiple drugs. This mechanism is partly caused by the overexpression of “ATP Binding Cassette” transporters (Pgp, MRP1, BCRP…). Known inhibitors of these transporters such as cyclosporin A, verapamil and RU486 rather toxic at high doses. In this study, many steroid derivatives synthesized in the laboratory (from progesterone or bile acid precursor) to bind and inhibit ABC transporters, specifically the transport by Pgp or BCRP. Several of these synthetic derivatives were able to completely restore the sensivity of the resistant cells compared to cysclosporine A in vitro. In addition, the efficient of these derivatives could, in vivo significantly reduce tumor growth of xenografts on mice and increase survival time of mice. This study opens a route for development of new steroid derivatives with low toxicity, having the ability to reverse the MDR phenotype and restore sensitivity of cancer cells to the chemotherapeutic agents use, with a perspective at clinical use
landing page: https://theses.hal.science/tel-00877481
identifier: NNT: 2009LYO10223
keyword: cancer
keyword: glycoproteine-p
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mdr-phenotype
keyword: p-glycoprotein
keyword: phenotype-mdr
keyword: progesterone
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: steroid
keyword: steroides
keyword: theses
issued: 2026-05-09T05:45:35.873688
modified: 2026-05-09T05:45:35.873693
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Reversion of MultiDrugResistance (MDR) phenotype by new steroids derivatives, in vitro (resistant human tumor cell line) and in vivo (xenografts models)
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00877481
issued: 2026-05-09T05:45:35.876140
modified: 2026-05-09T05:45:35.856647