Immunological selective preconcentration in nanofluidics : towards a fast identification of pathogenic agents
type: Dataset
description: Nanofluidics is the study of the transport of molecules through filtering nanostructures whose size approximates the thickness of the diffuse double layer at the surface of the glass. At this scale of hundreds of nanometers, the surface charge induces an exclusion of negative species outside the "nanofilter" and a retention effect of biomolecule. Studies on the electrokinetic transport in a single nanochannel have shown that it was theoretically possible to concentrate solutions, even highly diluted, with high rates (up to 103) thanks to a concentration polarization effect. This phenomenon can be exploited in many medical diagnostic applications (early and fast sample analysis), quality control (food, water) or defense (continuous monitoring of risky areas for biological terrorist threat). Modeling the dynamics of electropreconcentration phenomena (under an electric field) and retention phenomena (under a pressure gradient) of a single nanochannel is extremely difficult. A multitude of observations, often contradictory regarding the obtained preconcentration profile, were also reported with focal points observed sometimes in the anodic side and other times in the cathodic side for the same protein . Some experiments observe these focal points either upstream in the microchannel reservoir or directly at the entrance of the nanochannel. In this context, a one-dimensional model was previously developed to predict the concentration profile of the analyte at any point of the proposed MNM (Micro/Nano/Microchannel) structure. This modeling work has demonstrated the existence of four distinct regimes: two regimes in the anodic side and two regimes in the cathodic side, more or less distant from the nanochannel. This model highlighted the selectivity of the process regarding the electrophoretic mobility and the valence of the preconcentrated analytes and allowed to understand a little better the diversity of reported experiments. However, the obtained regime depends on the b…
landing page: https://theses.hal.science/tel-00876894
identifier: NNT: 2013PA112150
keyword: electrophoresis
keyword: infoeu-reposemanticsdoctoralthesis
keyword: microfluidique
keyword: nanofluidique
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: preconcentration
keyword: separation
keyword: theses
keyword: transport-electrocinetique
issued: 2026-05-09T06:12:00.105840
modified: 2026-05-09T06:12:00.105845
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Immunological selective preconcentration in nanofluidics : towards a fast identification of pathogenic agents
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00876894
issued: 2026-05-09T06:12:00.125391
modified: 2026-05-09T06:12:00.095547