@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00875713v1> a dcat:Dataset ;
    dct:description """
              The Mesenchymal-Amoeboid transition (MAT) is required for metastatic escape, however it has not been associated with a precise physiopathological requirement yet. PAI-1, type-1 plasminogen activator inhibitor, is a tumor matrix molecule considered as marker of bad prognosis and found in high amount in the most aggressive tumors. We show that, in its activated matrix form, PAI-1 is able to maintain, in time and with concentration-dependence, the amoeboid morphology of colorectal and mammary cancer cells, and that this one is associated with a weak integrin-independant adhesion, an amoeboid migration and the activation of RhoA/ROCK-1/MLC-P pathway. The involved molecular mechanism has been partially underlined: we show that immobilization of PAI-1 and its link with uPA are essential, and we assume that the membrane receptor uPAR participates in the transmission of signals maintaining activated the RhoA/ROCK-1/MLC-P pathway. The compatibility of matrix PAI-1 effects towards the main signaling pathways involved in MAT regulation is established in silico with a method based on the modeling of interaction network dynamics. All this results enable for the first time to characterize a matrix physiopathological situation supporting MAT; and although the matrix form of PAI-1 has not been revealed all its secrets yet, it seems to be an interesting therapeutic target.
            """ ;
    dct:identifier "tel-00875713" ;
    dct:issued "2026-05-09T07:00:35.543650"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-09T07:00:35.543655"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Study on the influence of matrix PAI-1 on the regulation of Mesenchymal-Amoeboid transition of cancer cells" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00875713v1/resource/87548335-600c-41f5-9863-8ca28aad6fa0> ;
    dcat:keyword "amoeboid-migration",
        "echappement-metastasique",
        "infoeu-reposemanticsdoctoralthesis",
        "mat",
        "metastatic-escape",
        "microenvironnement",
        "migration-amiboide",
        "pai-1",
        "sdvbclife-sciences-q-biocellular-biology",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00875713> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00875713v1/resource/87548335-600c-41f5-9863-8ca28aad6fa0> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T07:00:35.550276"^^xsd:dateTime ;
    dct:modified "2026-05-09T07:00:35.533144"^^xsd:dateTime ;
    dct:title "Study on the influence of matrix PAI-1 on the regulation of Mesenchymal-Amoeboid transition of cancer cells" ;
    dcat:accessURL <https://theses.hal.science/tel-00875713> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00875713> a foaf:Document .