The role of E2F2 and 1D3 transcription factors in tumor progression and therapeutic potential of targeting aminopeptidae N/CD13 in human colon cancer
type: Dataset
contact point: Organization
  fn: CCSD
keyword: colon-tumors
keyword: integrines
keyword: aminopeptidase-n
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
keyword: xenogreffe
keyword: theses
keyword: infoeu-reposemanticsdoctoralthesis
keyword: cancer-du-colon
keyword: jonctions-cellulaires
keyword: sdvcanlife-sciences-q-biocancer
keyword: invasion
keyword: e2f2
keyword: aminopeptidadse-n
keyword: cycle-cellulaire
landing page: https://theses.hal.science/tel-00871983
description: A genomic analysis (Comparative Genomic Hybridization) evidenced, among other chromosomic alterations, a microdeletion at 1p36.12 locus in 23% and 47% of colon adenomas and carcinomas, respectively. Among the 15 genes located in the deleted region, we focused on E2F2 gene involvedin various cellular processes. The Kaplan-Meier curve analysis showed that E2F2 deletion is associated with a better progression-free survival. To better understand the involvement of genes targeted by the microdeletion in colon tumors, we assessed the functional impact of the underexpression of E2F2 and of its direct neighbor gene ID3, coding for a dominant-negative repressor involved in cell differentiation. Our results indicated that E2F2 loss favors tumor growth and prevent metastatic spread. In collaboration with the biochemical team directed by the Pr Céline TARNUS, we started a pilotstudy to prove the anti-tumor potential of new chemical inhibitors highly selective of the aminopeptidase N.
identifier: NNT: 2012STRAJ122
issued: 2026-05-09T10:00:49.115777
language: fr
modified: 2026-05-09T10:00:49.115781

The role of E2F2 and 1D3 transcription factors in tumor progression and therapeutic potential of targeting aminopeptidae N/CD13 in human colon cancer
type: Distribution
access URL: https://theses.hal.science/tel-00871983
format: HTML
issued: 2026-05-09T10:00:49.156172
modified: 2026-05-09T10:00:49.100326

test_moissonnage_selune
type: Agent