Photo-activation Therapy with Nanoparticles : modeling at a Sub-Micrometer Level and Experimental Comparison
type: Dataset
description: An innovative approach using X-ray interactions with heavy elements seems to open a promising way of treatment for resistant cancers, such as high-grade gliomas. Such a technique is developed at the medical beam line of ESRF using monochromatic X-rays in the 25-90 keV range for the treatment of brain tumors [Adam 2003, Adam 2006]. The use of gold nanoparticles (AuNP) to treat mice bearing subcutaneous tumors led to encouraging results [Hainfeld 2004]. However, the physical processes and biological impact of the photon activation of nanoparticles are not yet well understood. The experimental results cannot be explained by macroscopic dose calculations [Cho 2005, Zhang 2009]. The aim of this work was to evaluate, at the sub-cellular level, the dose enhancement in presence of nanoparticles and the properties of the secondary electrons production using Monte Carlo simulations. In a first step, simulations were performed using cell geometry, in order to compare the simulated data to the experiments realized on the ID17 beamline of ESRF. Clonogenic assays have been performed on F98 cells to measure the “Sensitizer Enhancement Ratio” for an irradiation of 4 Gy (SER4Gy) in the presence of gadolinium, for several beam energies (25 to 80 keV). These experimental and numerical studies were done to evaluate the influence of the gadolinium location within the cell and its shape (nanoparticles or contrast agent). On the other hand, a comparative study has been performed to evaluate the behavior of a nanoparticle under irradiation at a nanometer scale. Electron spectra have been studied for two heavy elements - gold and gadolinium - and several beam energies from 25 keV to 2 MeV. Experiments have shown that gadolinium nanoparticles (GdNP) incubated during 5 h with the cells were strongly effective compared to non-incubated nanoparticles and contrast agent, for the same concentration of gadolinium. A part of radiosensitivity could possibly be explained by a biological action of GdN…
landing page: https://theses.hal.science/tel-00868799
identifier: NNT: 2013PA112028
keyword: basse-energie
keyword: electrons
keyword: infoeu-reposemanticsdoctoralthesis
keyword: low-energy
keyword: modeling
keyword: modelisation
keyword: monte-carlo
keyword: nanoparticles
keyword: nanoparticules
keyword: photoactivation
keyword: photon-activation
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: radiobiologie
keyword: radiobiology
keyword: radiosensibilite
keyword: radiosensitization
keyword: radiotherapie
keyword: radiotherapy
keyword: rx
keyword: simulation
keyword: theses
keyword: x-ray
issued: 2026-05-09T12:38:10.371165
modified: 2026-05-09T12:38:10.371170
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Photo-activation Therapy with Nanoparticles : modeling at a Sub-Micrometer Level and Experimental Comparison
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00868799
issued: 2026-05-09T12:38:10.401267
modified: 2026-05-09T12:38:10.351051