@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00867773v1> a dcat:Dataset ;
    dct:description """
              The aim of this work was to develop a new radiopharmaceutical for lung perfusion scintigraphy that does not carries, contrary to radiopharmaceuticals derived from human albumin currently used, the risk of transmitting infectious agents. For this purpose, a new starch-based microparticulate system has been conceived. In order to form stable complexes with Technetium-99m, the starch microparticles were modified by oxidation and functionalized with a polyamine ligand. Optimization of the formulation was carried out using experimental plans. The starch-based microparticles (SBMP) were characterized and the subject of in vitro and in vivo Technetium-99m labeling stability studies. The most promising SBMP formulation was investigated during further biodistribution and imaging studies on healthy animals and in a model of pulmonary embolism. With an average size between 20 and 30 μm, a high radiochemical purity (> 95%), the ability to be formulated as ready-to-use kits and to be sterilized by gamma radiation, the SBMP possess also a good labeling stability and meet therefore the requisites of an effective radiopharmaceutical for lung perfusion scintigraphy.
            """ ;
    dct:identifier "tel-00867773" ;
    dct:issued "2026-05-09T13:24:37.711740"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-09T13:24:37.711744"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Design, development and evaluation of a new radiopharmaceutical for the lung perfusion scintigraphy" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00867773v1/resource/115f08be-8514-4165-9945-cfc529f0f5b9> ;
    dcat:keyword "amidon",
        "cadaverine",
        "human-serum-albumine-macroaggregates",
        "infoeu-reposemanticsdoctoralthesis",
        "lung-perfusion-scintigraphy",
        "macroagregats-dalbumine-humaine",
        "microparticles",
        "microparticules",
        "radiopharmaceutical",
        "radiopharmaceutique",
        "scintigraphie-de-perfusion-pulmonaire",
        "sdvotlife-sciences-q-bioother-q-bioot",
        "starch",
        "technetium-99m",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00867773> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00867773v1/resource/115f08be-8514-4165-9945-cfc529f0f5b9> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T13:24:37.713818"^^xsd:dateTime ;
    dct:modified "2026-05-09T13:24:37.697129"^^xsd:dateTime ;
    dct:title "Design, development and evaluation of a new radiopharmaceutical for the lung perfusion scintigraphy" ;
    dcat:accessURL <https://theses.hal.science/tel-00867773> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00867773> a foaf:Document .