@prefix dcat: . @prefix dct: . @prefix foaf: . @prefix vcard: . @prefix xsd: . a dcat:Dataset ; dct:description """ The overlap of neurotoxic mecanisms involved in prion diseases and synucleinopathies, and the concomitant detection of pathological forms of prion and α-synuclein in a same neurodegenerative disease, raise questions about the existence of potential relationship between α‐synuclein molecular alteration and prion diseases. First, we developed monoclonal antibodies by immunizing mice presenting a spontaneous deletion of the α-synuclein gene with human recombinant α‐synuclein. Then, we characterized the molecular alterations appearing jointly to clinical signs during the aging of a transgenic mouse model of synucleinopathies (TgM83), overexpressing human A53T α‐synuclein. Then, an approach routinely done in the field of prion was used to trigger a synucleinopathy alongside a prion disease. For this purpose, TgM83 mice were inoculated intracerebrally by three different prion strains : transmission of H-type bovine spongiform encephalopathy allows the onset of a prion disease concomitantly to the α‐synuclein pathology developed by the TgM83 mouse model. Finally, intracerebral inoculation of TgM83 mice with brain homogenates from symptomatic mice affected by a synucleinopathy triggers an important acceleration of the α‐synuclein pathology, resulting in the early onset of motor clinical signs associated with molecular alterations of α-synuclein. These data suggest that α-synuclein alterations can be experimentally transmitted from one mouse to another, supporting the idea that, far from being confined to the transmissible spongiform encephalopathies, the « prion-like » propagation of misfolded neuronal proteins might occur in synucleinopathies """ ; dct:identifier "NNT: 2011LYO10057" ; dct:issued "2026-05-09T16:24:37.120977"^^xsd:dateTime ; dct:language "fr" ; dct:modified "2026-05-09T16:24:37.120982"^^xsd:dateTime ; dct:publisher ; dct:title "Alpha-synuclein molecular pathology : potential relationship with prion diseases" ; dcat:contactPoint [ a vcard:Organization ; vcard:fn "CCSD" ] ; dcat:distribution ; dcat:keyword "encephalopathie-spongiforme-transmissible-est", "infoeu-reposemanticsdoctoralthesis", "lpha-synuclein", "lpha-synucleine", "maladie-neurodegenerative", "neurodegenerative-disease", "parkinson", "prion", "sdvsalife-sciences-q-bioagricultural-sciences", "synucleinopathie", "synucleinopathy", "theses", "transmissible-spongiform-encephalopathies-est" ; dcat:landingPage . a dcat:Distribution ; dct:format "HTML" ; dct:issued "2026-05-09T16:24:37.131090"^^xsd:dateTime ; dct:modified "2026-05-09T16:24:37.107665"^^xsd:dateTime ; dct:title "Alpha-synuclein molecular pathology : potential relationship with prion diseases" ; dcat:accessURL . a foaf:Agent ; foaf:name "test_moissonnage_selune" . a foaf:Document .