Multiscale study of the effects of bisphosphonates on bone quality in postmenopausal osteoporotic women
type: Dataset
description: Postmenopausal osteoporosis is characterized by an increase in remodelling activity leading to a low bone mass and alterations in microarchitecture, increasing the risk of fracture. Bisphosphonates slowdown remodeling inhibiting bone resorption, thus bone mineral density is preserved with a decrease in the risk of fracture. Such a treatment is often chronic, making the study of their long-term effects on multiscale bone quality (from the crystal to the macrostructure) of clinical relevance. Thank to two different studies on ibandronate and alendronate, we showed that these treatments preserved the mineralization of bone tissue. However, we firstly described that a long-term treatment with alendronate alter the structure of bone mineral crystals with a direct effect on micromechanical properties. Even if, the reduction in the risk of fracture under alendronate has been established after a ten year treatment, our results suggest alterations in bone quality at tissular and sub-tissular levels of organization
identifier: NNT: 2011LYO10118
issued: 2026-05-09T16:49:36.061703
language: fr
modified: 2026-05-09T16:49:36.061707
contact point: Organization
  fn: CCSD
keyword: biomecanique
keyword: biomechanics
keyword: bisphosphonates
keyword: bone-quality
keyword: infoeu-reposemanticsdoctoralthesis
keyword: mineralisation
keyword: mineralization
keyword: osteoporose
keyword: osteoporosis
keyword: qualite-osseuse
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
landing page: https://theses.hal.science/tel-00863494

Multiscale study of the effects of bisphosphonates on bone quality in postmenopausal osteoporotic women
type: Distribution
format: HTML
issued: 2026-05-09T16:49:36.068690
modified: 2026-05-09T16:49:36.048477
access URL: https://theses.hal.science/tel-00863494

test_moissonnage_selune
type: Agent