Respiratory biodistribution and toxicity of carbon nanotubes in normal mice and in murine allergic asthma model
type: Dataset
description: With the development of nanotechnologies, the question arises about the respiratory toxicity and the impact of the manufactured nanoparticles on the respiratory diseases such as allergic asthma. The aim of this thesis was to study the respiratory toxicity and biodistribution of carbon nanotubes (CNT), which are emblematic figures of nanotechnologies, in normal mice and in a murine asthma model. This work was conducted on multi-walled CNT, which represent more than 95% of the industrial production of CNT. Our data showed that CNT distribute uniformly in the mouse airways, that they areinternalized by different resident and infiltrated cells (macrophages, type II pneumocytes, neutrophils), and that they are able, according to the dose and duration of exposure, to induce an inflammatory response and a tissue remodeling. Our data also showed that CNT can promote the response to an allergen, and suggested that epithelial cells play a role in this effect. Thus, exposure to CNT could represent a risk for the respiratory health of healthy subjects and asthmatics.
identifier: NNT: 2012STRAJ025
issued: 2026-05-09T17:17:14.173077
language: fr
modified: 2026-05-09T17:17:14.173082
contact point: Organization
  fn: CCSD
keyword: asthma
keyword: asthme
keyword: biodistribution
keyword: carbon-nanotubes
keyword: infoeu-reposemanticsdoctoralthesis
keyword: nanotechnologies
keyword: nanotechnology
keyword: nanotubes-de-carbone
keyword: respiratory-toxicity
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: sdvtoxecolife-sciences-q-biotoxicologyecotoxicology
keyword: theses
keyword: toxicite-respiratoire
landing page: https://theses.hal.science/tel-00862972

Respiratory biodistribution and toxicity of carbon nanotubes in normal mice and in murine allergic asthma model
type: Distribution
format: HTML
issued: 2026-05-09T17:17:14.174672
modified: 2026-05-09T17:17:14.157655
access URL: https://theses.hal.science/tel-00862972

test_moissonnage_selune
type: Agent