Design, synthesis and biological evaluation of new platelet aggregation inhibitors and novel methodologies for the preparation of CF₂R containing molecules
type: Dataset
description: The first part of the thesis deals with the synthesis and biological evaluation of new platelets aggregation inhibitors, based on 12-HETE, 13-HODE and their analogues. In the second part we are interested in novel methodologies for the preparation of CF₂-containing molecules : First, a flexible strategy for the synthesis of gem-difluoro-bisarylic derivatives and heteroaromatic analogues was designed based on the easy synthesis and the reactivity of gem-difluoro propargylic intermediates, which by Diels-Alder cycloaddition and 1,3-dipolar cycloadditions afforded respectively the bisarylic and mixed arylic heteroarylic scaffolds. In addition, two small libraries were constructed around a bisarylic scaffold as representative examples. Second, we were interested in the synthesis of optically active functionalized molecules containing a gem-difluoro group, using asymmetric organocatalysis protocols. After preparation of the gem-difluoro enals, from their difluoropropargylic precursors, asymmetric organocalytic Diels-Alder cycloaddition and 1,4-conjugated additions were successfully performed.
landing page: https://theses.hal.science/tel-00861475
identifier: NNT: 2013REN1S010
keyword: addition-de-michael
keyword: anti-thrombotic
keyword: anti-thrombotique
keyword: asymmetric-organocatalysis
keyword: chemical-library
keyword: chimie-du-fluor
keyword: chimie-medicinale
keyword: chimiotheque
keyword: chimothechemical-sciencesother
keyword: composes-gem-difluores
keyword: cyclooxygenase-1
keyword: fluorine-chemistry
keyword: gem-difluoro-compounds
keyword: infoeu-reposemanticsdoctoralthesis
keyword: inhibiteurs
keyword: inhibitors
keyword: medicinal-chemistry
keyword: michael-addition
keyword: organo-catalyse-asymetrique
keyword: theses
issued: 2026-05-09T18:25:38.138182
modified: 2026-05-09T18:25:38.138187
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Design, synthesis and biological evaluation of new platelet aggregation inhibitors and novel methodologies for the preparation of CF₂R containing molecules
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00861475
issued: 2026-05-09T18:25:38.143365
modified: 2026-05-09T18:25:38.116654