@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              The first part of the thesis deals with the synthesis and biological evaluation of new platelets aggregation inhibitors, based on 12-HETE, 13-HODE and their analogues. In the second part we are interested in novel methodologies for the preparation of CF₂-containing molecules : First, a flexible strategy for the synthesis of gem-difluoro-bisarylic derivatives and heteroaromatic analogues was designed based on the easy synthesis and the reactivity of gem-difluoro propargylic intermediates, which by Diels-Alder cycloaddition and 1,3-dipolar cycloadditions afforded respectively the bisarylic and mixed arylic heteroarylic scaffolds. In addition, two small libraries were constructed around a bisarylic scaffold as representative examples. Second, we were interested in the synthesis of optically active functionalized molecules containing a gem-difluoro group, using asymmetric organocatalysis protocols. After preparation of the gem-difluoro enals, from their difluoropropargylic precursors, asymmetric organocalytic Diels-Alder cycloaddition and 1,4-conjugated additions were successfully performed.
            """ ;
    dct:identifier "NNT: 2013REN1S010" ;
    dct:issued "2026-05-09T18:25:38.138182"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T18:25:38.138187"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Design, synthesis and biological evaluation of new platelet aggregation inhibitors and novel methodologies for the preparation of CF₂R containing molecules" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00861475v1/resource/6f78ec09-5a58-402c-b405-e20e5f32c31a> ;
    dcat:keyword "addition-de-michael",
        "anti-thrombotic",
        "anti-thrombotique",
        "asymmetric-organocatalysis",
        "chemical-library",
        "chimie-du-fluor",
        "chimie-medicinale",
        "chimiotheque",
        "chimothechemical-sciencesother",
        "composes-gem-difluores",
        "cyclooxygenase-1",
        "fluorine-chemistry",
        "gem-difluoro-compounds",
        "infoeu-reposemanticsdoctoralthesis",
        "inhibiteurs",
        "inhibitors",
        "medicinal-chemistry",
        "michael-addition",
        "organo-catalyse-asymetrique",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00861475> .

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    dct:format "HTML" ;
    dct:issued "2026-05-09T18:25:38.143365"^^xsd:dateTime ;
    dct:modified "2026-05-09T18:25:38.116654"^^xsd:dateTime ;
    dct:title "Design, synthesis and biological evaluation of new platelet aggregation inhibitors and novel methodologies for the preparation of CF₂R containing molecules" ;
    dcat:accessURL <https://theses.hal.science/tel-00861475> .

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