@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00858884v1> a dcat:Dataset ;
    dct:description """
              The MSRV (Multiple Sclerosis Associated Retro Virus) belongs to the human endogenous retrovirus HERV-W family. An envelope protein originating from the MSRV was found in most patients with multiple sclerosis (MS). This protein (Env-ms) has pro-inflammatory properties on several immune cells and could therefore play a role in the MS pathogenesis by promoting the leukocyte diapedesis observed in the central nervous system of patients. Our study aims to analyze the effects of Env-ms on the blood-brain barrier (BBB) at a molecular and functional level. We have demonstrated that the recombinant MSRV envelope was able to strongly stimulate several inflammatory parameters on a human BBB in vitro model, the HCMEC/D3 cell line. Indeed, Env-ms induced overexpression of ICAM-1, a major mediator of leukocyte adhesion to endothelial cells, in a dose-dependent manner and a strong dose-dependent production of the pro-inflammatory cytokines IL-6 and IL-8. Furthermore, using a silencing approach with siRNAs, we have shown that Env-ms was recognized via the TLR4 receptor, a pattern recognition receptor of innate immunity present on endothelial cells. Indeed, the knock down of TLR4 abolishes the pro-inflammatory effects of Env-ms. We have also shown using functionnal assays, that the treatment of brain endothelial cells with Env-ms significantly stimulated the adhesion of activated immune cells to the monolayer of endothelial cells. We also assessed the effects of Env-ms on primary endothelial cells HUVECs and we observed that the pro-inflammatory properties of the envelope protein were similar to those observed on HCMEC/D3. These findings support the hypothesis that MSRV could be involved in the pathogenesis of MS disease or at least in maintenance of inflammatory conditions thus fueling the auto-immune disorder. The MSRV could also play a role in other chronic inflammatory diseases.
            """ ;
    dct:identifier "NNT: 2012GRENV038" ;
    dct:issued "2026-05-09T20:36:29.502257"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-09T20:36:29.502262"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Roles of human endogenous retroviruses in vascular endothelium inflammation." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00858884v1/resource/24fb548d-e6aa-451a-8247-f09e8cc3a2f7> ;
    dcat:keyword "barriere-hemato-encephalique",
        "blood-brain-barrier",
        "herv",
        "inflammation",
        "infoeu-reposemanticsdoctoralthesis",
        "msrv",
        "multiple-sclerosis",
        "sclerose-en-plaques",
        "sdvsalife-sciences-q-bioagricultural-sciences",
        "theses" ;
    dcat:landingPage <https://theses.hal.science/tel-00858884> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00858884v1/resource/24fb548d-e6aa-451a-8247-f09e8cc3a2f7> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T20:36:29.509323"^^xsd:dateTime ;
    dct:modified "2026-05-09T20:36:29.488728"^^xsd:dateTime ;
    dct:title "Roles of human endogenous retroviruses in vascular endothelium inflammation." ;
    dcat:accessURL <https://theses.hal.science/tel-00858884> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00858884> a foaf:Document .