@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00857574v1> a dcat:Dataset ;
    dct:description """
              Due to the emergence of multiresistant bacterial strains to standard antibacterial treatments, thiopeptides antibiotics are actually highly considered, though they are known for 60 years. They show an excellent antibiotic activity against multiresistant bacterial strains, and implement two originals inhibition mechanisms of protein synthesis, still unemployed in human therapy. However, the difficulty to prepare these complex macromolecules limits their pharmacological development. The development of a new strategy to synthetize the most complicated part of these macromolecules, their heterocyclic core, is studied here in. This approach is based on the study and the exploitation of novel direct C-H and C-X transition-metal-catalyzed couplings of mono- and bithiazoles units with a broad panel of heteroaromatics. Its viability is here demonstrated trough the multi-step synthesis of the common heterocyclic core of amythiamicins.
            """ ;
    dct:identifier "NNT: 2012ISAM0024" ;
    dct:issued "2026-05-09T21:44:12.361808"^^xsd:dateTime ;
    dct:language "fr" ;
    dct:modified "2026-05-09T21:44:12.361813"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Development of new C-H and C-X direct arylation methodologies in thiazole and pyridine series : application to the synthesis of the heterocyclic core of thiopeptides antibiotics in the d series" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00857574v1/resource/d84ba621-6a33-4bf9-9b72-bd734e2dc2cf> ;
    dcat:keyword "antibiotiques-peptidiques",
        "arylation-directe",
        "borylation",
        "bsc",
        "chimothechemical-sciencesother",
        "couplage-de-suzuki-miyaura",
        "heterocycles",
        "infoeu-reposemanticsdoctoralthesis",
        "pyridine",
        "suzuki-miyaura-coupling",
        "synthese-multi-etapes",
        "theses",
        "thiazole",
        "thiopeptides-antibiotics",
        "thiopeptides-antibiotiques",
        "thiostrepton" ;
    dcat:landingPage <https://theses.hal.science/tel-00857574> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-tel-00857574v1/resource/d84ba621-6a33-4bf9-9b72-bd734e2dc2cf> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T21:44:12.373248"^^xsd:dateTime ;
    dct:modified "2026-05-09T21:44:12.346786"^^xsd:dateTime ;
    dct:title "Development of new C-H and C-X direct arylation methodologies in thiazole and pyridine series : application to the synthesis of the heterocyclic core of thiopeptides antibiotics in the d series" ;
    dcat:accessURL <https://theses.hal.science/tel-00857574> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .

<https://theses.hal.science/tel-00857574> a foaf:Document .