Acquisition of malaria specific antibody responses in infants : host, parasite and environmental factors
type: Dataset
description: Four epidemiological studies showed that infants born from mothers with Plasmodium falciparum placental malaria at delivery present a higher susceptibility to plasmodial infections than others. In connection with this observation, we hypothesized that i) the infants’ P. falciparum specific antibody responses are different according to presence or absence of placental malaria at delivery in their mothers and ii) susceptibility could only be induced by antigens that bring the same polymorphisms as those found in infected mothers. Another project consisted to develop a new methodology to distinguish maternal and neonatal antibodies in order to measure accurately neo-synthesized antibodies in the first months of life. A birth cohort of 620 newborns was established in an area endemic for malaria. Infants were followed-up until 18 months of age and their antibody responses specific for 7 P. falciparum antigens were quarterly measured. The emergence of the immune maturation process was observed in 18-months-infants. The acquisition of specific antibody responses was not impacted by placental malaria. The new methodological approach leading to distinguish maternal and neonatal antibodies was validated. The genetic characterization of the parasite antigen polymorphisms in mothers at delivery and their infants during the follow-up, in link to environmental data, led partially to the validation of the immune tolerance hypothesis.
landing page: https://theses.hal.science/tel-00856581
identifier: NNT: 2012PA05P608
keyword: enfants
keyword: humoral-immune-response
keyword: infants
keyword: infection-palustre-placentaire
keyword: infoeu-reposemanticsdoctoralthesis
keyword: malaria
keyword: paludisme
keyword: placental-malaria
keyword: reponse-immune-humorale
keyword: sdvmheplife-sciences-q-biohuman-health-and-pathology
keyword: theses
issued: 2026-05-09T22:36:35.196032
modified: 2026-05-09T22:36:35.196036
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Acquisition of malaria specific antibody responses in infants : host, parasite and environmental factors
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00856581
issued: 2026-05-09T22:36:35.204203
modified: 2026-05-09T22:36:35.183869