Polydiacetylenic self-assemblies and biological applications
type: Dataset
description: The hydrophobic/hydrophilic duality of amphiphilic molecules is at the origin of their selfassembly in solution, into many supramolecular structures such as micelles. This thesis presents the formation, characterization and study of new photopolymerizable diacetylenic micelles. The first part describes the synthesis of new cationic micelles and the study of theiruse as gene transfer agent. In the second part, our work presents the study of polydiacetylene micelles, bearing polar heads octaétylèneglycol as potential drug delivery system. The encapsulation properties of these micelles were first evaluated in the presence of a fluorescent fullerene derivative. Then, the incorporation of a membrane probe in their lipophilic shell has allowed a study of their in vitro delivery properties. Finally a study of their in vivo biodistribution was also carried out by single photon emission tomography through the chelation of a radioactive isotope on micelle surface. Finally the last part presents theanalysis of two new tubularself-assemblies, obtained during our work.
landing page: https://theses.hal.science/tel-00855285
identifier: NNT: 2012STRAF063
keyword: amphiphiles
keyword: auto-assemblages
keyword: chimothechemical-sciencesother
keyword: delivrance-de-medicaments
keyword: drug-delivery
keyword: infoeu-reposemanticsdoctoralthesis
keyword: micelles
keyword: polydiacetylenes
keyword: self-assembling
keyword: theses
keyword: transfection
issued: 2026-05-09T23:42:22.962836
modified: 2026-05-09T23:42:22.962841
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Polydiacetylenic self-assemblies and biological applications
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00855285
issued: 2026-05-09T23:42:22.968772
modified: 2026-05-09T23:42:22.949728