Characterization of the structure-function relationship in the human brain using functional and diffusion MRI : cognitive and clinical methods and applications
type: Dataset
description: Recent advances in Magnetic Resonance Imaging are allowing neuroscientists to gain critical insights into the neural networks mediating a variety of cognitive processes. Neural networks are sets of anatomically and functionally interconnected regions and are the origin of cognitive pro- cesses. In this work, we studied the relationship between structure and function in these networks, through the two fundamental principles of brain function, namely segregation and integration, and the concept of integrity. First, we focused on the anatomical segregation of basal ganglia and its functional interpretation. Then we examined the principle of integration, from a descriptive way to an explanatory approach, by using the spatial autoregressive model. Finally, we studied the structu- ral integrity of the brain in the presence of mild traumatic brain injury associated neurobehavioral deficits. We demonstrated the existence of an anatomical substrate underlying the functional net- works. Our results suggest that the anatomical structure of brain networks is a complex substrate optimizing cognitives processes. Moreover, loss of structural integrity in mild traumatic brain injury affects behavior and cognitive performances. This demonstrates that brain function, mediated by neural networks, is intimately related to their anatomical structure.
landing page: https://theses.hal.science/tel-00845014
keyword: connectivite
keyword: connectivity
keyword: fonction
keyword: function
keyword: generative-model
keyword: graph-theory
keyword: infoeu-reposemanticsdoctoralthesis
keyword: infoinfo-mocomputer-science-csmodeling-and-simulation
keyword: infoinfo-tscomputer-science-cssignal-and-image-processing
keyword: integration
keyword: integrite
keyword: integrity
keyword: irm
keyword: mild-traumatic-brain-injury
keyword: modele-generatif
keyword: mri
keyword: network
keyword: reseau
keyword: sdviblife-sciences-q-biobioengineering
keyword: sdvneulife-sciences-q-bioneurons-and-cognition-q-bionc
keyword: segregation
keyword: spisignalengineering-sciences-physicssignal-and-image-processing
keyword: structure
keyword: theorie-des-graphes
keyword: theses
keyword: traumatisme-cranien-leger
issued: 2026-05-10T08:19:10.028552
modified: 2026-05-10T08:19:10.028557
language: fr
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Characterization of the structure-function relationship in the human brain using functional and diffusion MRI : cognitive and clinical methods and applications
type: Distribution
format: HTML
access URL: https://theses.hal.science/tel-00845014
issued: 2026-05-10T08:19:10.030603
modified: 2026-05-10T08:19:10.002215