Poly(oxyde d'éthylène)s fonctionnels à extrémité acide phosphonique et à fonctionnalité réversible pour la stabilisation de nanoparticules magnétiques
type: Dataset
contact point: Organization
  fn: CCSD
keyword: phosphonic-acid-terminated-polyethylene-oxide
keyword: chimie-click
keyword: diels-alder-reaction
keyword: click-reaction
keyword: theses
keyword: reaction-de-diels-alder
keyword: polyoxyde-dethylene-a-extremite-acide-phosphonique
keyword: infoeu-reposemanticsdoctoralthesis
keyword: kabachnik-fields
keyword: chimcrischemical-sciencescristallography
keyword: nanoparticules-doxyde-de-fer
keyword: kabachnik-fields-reaction
keyword: iron-oxide-nanoparticles
landing page: https://theses.hal.science/tel-00844750
description: The objective of this thesis was the preparation ofbiocompatible hydrophilic functionalized polymers forthe stabilization and bio-functionalization of iron oxidenanoparticles (IONPs) for biomedical applications suchas contrast agents in magnetic resonance imagingand/or targeted drug delivery. In this work, commerciallyavailable poly(ethylene oxide)s (PEO), which havehydrophilic, biocompatibility and furtivity properties havebeen functionalized by a phosphonic acid group, thatstrong anchors on IONPs, and by a furan group that canbe coupled to maleimide-terminated biomolecules by athermoreversible Diels-Alder reaction.Phosphonic acid-terminated PEOs fonctionalized by afurane group were synthesized according to two originalstrategies combining an Atherton-Todd or a Kabachnik-Fields reaction and a 1,3-dipolar cycloaddition reaction.This latter reaction, also named ‘click’ reaction, ischaracterized by high yields, simple reaction conditions,fast reaction times, and high selectivity.These PEOs were attached to the IONPs surface usingthe 'grafting onto' strategy. The subsequent polymerstabilizedIONPs were characterized, proving thepresence of polymers on IONPs surfaces. Cytotoxicitystudies revealed that the IONPs carriers werebiocompatible. In addition, studies on the protontransverse relaxation enhancement properties of thesestabilized IONPs indicated high relaxivities in the samerange as iron oxide based commercially availablecontrast agents. Finally, polymer-stabilized IONPs weresuccessfully functionalized by maleimide-functionalizedmolecules according to the Diels-Alder reaction and thesubsequent release of these molecules via a thermalstimulus has been proven. Consequently, this type ofcontrolled-release system could be expanded to drugtherapy responding to external stimuli.
identifier: NNT: 2013LEMA1012
issued: 2026-05-10T08:30:22.571989
language: fr
modified: 2026-05-10T08:30:22.571994

test_moissonnage_selune
type: Agent

Poly(oxyde d'éthylène)s fonctionnels à extrémité acide phosphonique et à fonctionnalité réversible pour la stabilisation de nanoparticules magnétiques
type: Distribution
access URL: https://theses.hal.science/tel-00844750
format: HTML
issued: 2026-05-10T08:30:22.589666
modified: 2026-05-10T08:30:22.557898