Characterization of the tumors and their evolutions using PET/CT for treatment following
type: Dataset
description: Positron Emission Tomography (PET) using ¹⁸F-FluoroDeoxyGlucose (¹⁸F-FDG), a radiolabelled analogue of the glucose, is used to get an image of the glucose consumption in the body. As most tumor masses show a high glucose consumption, PET is widely used in oncology for diagnosis and patient monitoring. In the context of patient monitoring, the motivation is to decrease the time interval needed to assess treatment (radiotherapy or chemotherapy efficieny) compared to therapeutic follow-up based only on anatomic imaging only (Computed Tomography or Magnetic Resonance Imaging). My research project aimed at proposing and improving quantitative methods in FDG-PET to better characterize tumor evolution.In PET, many factors affect the accuracy of parameters estimated from the images. Among them, Partial Volume Effect (PVE) remains difficult to correct, mainly due to the low spatial resolution of PET images. To determine the impact of PVE on treatment response evaluation, a preliminary study was performed using Monte Carlo simulated PET scans. An additional study was conducted based on the analysis of the PET/CT (Computed Tomography) data of 40 Metastatic Colorectal Cancer (MCC) patients treated with chemotherapy at the Jules Bordet Institute (Brussels, Belgium). The analysis of the 101 tumors showed that criteria such as the Standardized Uptake Value (SUV), which does not include PVE correction, were better predictors of tumors evolutions than PVE corrected criteria. This is because without PVE correction, SUV includes information on both metabolic volume and metabolic activity, which are two relevant pieces of information to characterize the tumor. A second part of our work was to study the potential of tumor texture analysis in patient monitoring, following promising results reported in the literature. Texture analysis was applied to the MMC patients data previously mentioned but did allow to a better segregation of tumors responses as compared to indices currently used in…
identifier: NNT: 2012PA112404
issued: 2026-05-10T08:59:17.639225
language: fr
modified: 2026-05-10T08:59:17.639230
contact point: Organization
  fn: CCSD
keyword: afsim
keyword: analyse-factorielle
keyword: effet-de-volume-partiel
keyword: f-fdg
keyword: factor-analysis
keyword: fast
keyword: heterogeneite
keyword: heterogeneity
keyword: infoeu-reposemanticsdoctoralthesis
keyword: partial-volume-effect
keyword: petct
keyword: physcondcm-genphysics-physicscondensed-matter-cond-matother-cond-matother
keyword: quantification
keyword: suivi-therapeutique
keyword: suv
keyword: teptdm
keyword: texture
keyword: theses
keyword: treatment-following
landing page: https://theses.hal.science/tel-00844243

Characterization of the tumors and their evolutions using PET/CT for treatment following
type: Distribution
format: HTML
issued: 2026-05-10T08:59:17.646088
modified: 2026-05-10T08:59:17.619819
access URL: https://theses.hal.science/tel-00844243

test_moissonnage_selune
type: Agent