@prefix dcat: . @prefix dct: . @prefix foaf: . @prefix vcard: . @prefix xsd: . a dcat:Dataset ; dct:description """ Cancer surgery is still the gold standard therapy in most cancers. Nevertheless, total tumor resection and metastasis detection while preserving healthy tissues represent a crucial point for further prognosis. Development of imaging technologies for intra-operative guided surgery provided promising results and efficient application in preclinical studies and first clinical trials using non-specific tracers already confirmed the improved out-come in surgery. Moreover early and precise diagnosis and targeted therapies are major domains of cancer research. In this context our team previously developed a synthetic vector based on a cyclic decapeptide scaffold RAFT (Regioselectively Addressable Functionalized Template) which allows the independent functionalizing of two domains: a targeting domain with multivalent RGD-ligand targeting the cell receptor integrin αVβ3, and a vehicle domain grafted with a pro-drug or an imaging agent. One part of this work consisted in the evaluation of the combination of this molecule carrying a fluorophore with a portable fluorescent imaging device for image-guided surgery of natural occurring feline fibrosarcomas. This study represents a proof of concept for further translation into human clinics. No toxic effects in cats after administration of the tracer could be reported. Furthermore the tumors were specifically labeled showing a good tumor-to-healthy tissue ratio. This should improve tumor resection by helping the surgeon to delineate tumor margins. In parallel we developed a bi-functinal derivative of the RAFT-RGD. Therefore we engrafted a peptide sequence flanked by two fluorophores, which is activatable by matrixmetalloprotease-9, an enzyme overexpressed in tumors. This molecule showed an improved tumor labeling in vitro and in vivo compared to the conventional RAFT-RGD, suggesting an additional effect of the double targeting. These preliminary results encourage further caracterisation for its potential as pro-drug vehicle, as well as for studying interactions between the integrin and the tumor environment. """ ; dct:identifier "NNT: 2012GRENV063" ; dct:issued "2026-05-10T10:01:24.907629"^^xsd:dateTime ; dct:language "en" ; dct:modified "2026-05-10T10:01:24.907634"^^xsd:dateTime ; dct:publisher ; dct:title "Optical-guided surgery of the feline fibrosarcoma & Development and characterization of a bi-functional vector for cancer targeting" ; dcat:contactPoint [ a vcard:Organization ; vcard:fn "CCSD" ] ; dcat:distribution ; dcat:keyword "cancer", "chirurgie-guidee-par-la-fluorescence", "fluorescent-guided-cancer-surgery", "imagerie-de-fluorescence-in-vitro-et-in-vivo", "imagerie-per-operatoire", "in-vitro-and-in-vivo-fluorescence-imaging", "infoeu-reposemanticsdoctoralthesis", "inter-operative-imaging", "peptides-cibles", "raft-rgd", "sdvsalife-sciences-q-bioagricultural-sciences", "targeting-peptides", "theses", "tumeur" ; dcat:landingPage . a dcat:Distribution ; dct:format "HTML" ; dct:issued "2026-05-10T10:01:24.933763"^^xsd:dateTime ; dct:modified "2026-05-10T10:01:24.893317"^^xsd:dateTime ; dct:title "Optical-guided surgery of the feline fibrosarcoma & Development and characterization of a bi-functional vector for cancer targeting" ; dcat:accessURL . a foaf:Agent ; foaf:name "test_moissonnage_selune" . a foaf:Document .